TY  - JOUR
AU  - Luft, Thomas
AU  - Benner, Axel
AU  - Jodele, Sonata
AU  - Dandoy, Christopher E
AU  - Storb, Rainer
AU  - Gooley, Ted
AU  - Sandmaier, Brenda M
AU  - Becker, Natalia
AU  - Radujkovic, Aleksandar
AU  - Dreger, Peter
AU  - Penack, Olaf
TI  - EASIX in patients with acute graft-versus-host disease: a retrospective cohort analysis.
JO  - The lancet  / Haematology
VL  - 4
IS  - 9
SN  - 2352-3026
CY  - London [u.a.]
PB  - Elsevier
M1  - DKFZ-2017-04114
SP  - e414 - e423
PY  - 2017
AB  - Endothelial dysfunction links thrombotic microangiopathy to steroid-refractory graft-versus-host disease (GVHD) after allogeneic stem-cell transplantation. We aimed to assess if the simple formula-lactate dehydrogenase (U/L) × creatinine (mg/dL)/thrombocytes (10(9) cells per L)-termed the Endothelial Activation and Stress Index (EASIX), might be valuable for the prediction of death in patients with acute GVHD after allogeneic stem-cell transplantation.For this retrospective analysis, we analysed a training cohort (in Germany) and three validation cohorts (in Germany and the USA) of patients with acute GVHD who had received consecutive allogeneic stem-cell transplantation. The primary endpoint was prediction of overall survival when measured at acute GVHD onset (EASIX-GVHD). We validated the prognostic strength of EASIX-GVHD for overall survival and non-relapse mortality in the three independent cohorts by calculating the prediction error (integrated Brier score), and concordance index.In the total cohort of patients with acute GVHD (n=311), EASIX-GVHD predicted overall survival in univariable and multivariable models (univariate analysis, hazard ratio [HR] for a one-fold increase 1·16, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:28733186
DO  - DOI:10.1016/S2352-3026(17)30108-4
UR  - https://inrepo02.dkfz.de/record/128092
ER  -