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@ARTICLE{Rthke:128162,
      author       = {M. Röthke$^*$ and T. H. Kuru$^*$ and S. Schultze and D.
                      Tichy$^*$ and A. Kopp-Schneider$^*$ and M. Fenchel and H.-P.
                      Schlemmer$^*$ and B. A. Hadaschik},
      title        = {{E}valuation of the {ESUR} {PI}-{RADS} scoring system for
                      multiparametric {MRI} of the prostate with targeted
                      {MR}/{TRUS} fusion-guided biopsy at 3.0 {T}esla.},
      journal      = {European radiology},
      volume       = {24},
      number       = {2},
      issn         = {1432-1084},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DKFZ-2017-04180},
      pages        = {344 - 352},
      year         = {2014},
      abstract     = {To evaluate the Prostate Imaging Reporting and Data System
                      (PI-RADS) proposed by the European Society of Urogenital
                      Radiology (ESUR) for detection of prostate cancer (PCa) by
                      multiparametric magnetic resonance imaging (mpMRI) in a
                      consecutive cohort of patients with magnetic
                      resonance/transrectal ultrasound (MR/TRUS) fusion-guided
                      biopsy.Suspicious lesions on mpMRI at 3.0 T were scored
                      according to the PI-RADS system before MR/TRUS fusion-guided
                      biopsy and correlated to histopathology results. Statistical
                      correlation was obtained by a Mann-Whitney U test. Receiver
                      operating characteristics (ROC) and optimal thresholds were
                      calculated.In 64 patients, 128/445 positive biopsy cores
                      were obtained out of 95 suspicious regions of interest
                      (ROIs). PCa was present in 27/64 $(42\%)$ of the patients.
                      ROC results for the aggregated PI-RADS scores exhibited
                      higher areas under the curve compared to those of the Likert
                      score. Sensitivity/Specificity for the following thresholds
                      were calculated: 85 $\%/73$ $\%$ and 67 $\%/92$ $\%$ for
                      PI-RADS scores of 9 and 10, respectively; 85 $\%/60$ $\%$
                      and 56 $\%/97$ $\%$ for Likert scores of 3 and 4,
                      respectively [corrected.The standardised ESUR PI-RADS system
                      is beneficial to indicate the likelihood of PCa of
                      suspicious lesions on mpMRI. It is also valuable to identify
                      locations to be targeted with biopsy. The aggregated PI-RADS
                      score achieved better results compared to the single
                      five-point Likert score.• The ESUR PI-RADS scoring system
                      was evaluated using multiparametric 3.0-T MRI. • To
                      investigate suspicious findings, transperineal MR/TRUS
                      fusion-guided biopsy was used. • PI-RADS can guide biopsy
                      locations and improve detection of clinically significant
                      cancer. • Biopsy procedures can be optimised, reducing
                      unnecessary negative biopsies for patients. • The PI-RADS
                      scoring system may contribute to more effective prostate
                      MRI.},
      cin          = {E010 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24196383},
      doi          = {10.1007/s00330-013-3017-5},
      url          = {https://inrepo02.dkfz.de/record/128162},
}