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@ARTICLE{Sowade:128214,
      author       = {R. Sowade$^*$ and T. R. Jahn$^*$},
      title        = {{S}eed-induced acceleration of amyloid-β mediated
                      neurotoxicity in vivo.},
      journal      = {Nature Communications},
      volume       = {8},
      number       = {1},
      issn         = {2041-1723},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2017-04231},
      pages        = {512},
      year         = {2017},
      abstract     = {Seeded propagation of amyloid-beta (Aβ) pathology is
                      suggested to contribute to the progression of Alzheimers
                      disease. Local overproduction of aggregation-prone Aβ
                      variants could explain the focal initiation of a seeding
                      cascade that subsequently triggers widespread pathology.
                      Several animal models support this seeding concept by
                      demonstrating accelerated Aβ deposition following
                      inoculation with Aβ-containing homogenates, however its
                      role in progressive neurodegeneration remains unclear. Here,
                      we present a non-invasive approach to study Aβ seeding
                      processes in vivo using Drosophila models. We show that
                      small amounts of aggregation-competent Aβ42 seeds,
                      generated in selected neuronal clusters, can induce the
                      deposition of the pan-neuronally expressed and otherwise
                      soluble Aβ40. Moreover, our models visualize the
                      accelerated formation and propagation of amyloid pathology
                      throughout the brain, which correlates with severe
                      neurotoxicity. Taken together, these in vivo models provide
                      mechanistic insights into disease-related processes and
                      represent versatile genetic tools to determine novel
                      modifiers of the Aβ seeding cascade.Seeding of amyloid beta
                      from one brain region to another is thought to contribute to
                      the progression of Alzheimers disease, although to date most
                      studies have depended on inoculation of animals with
                      exogenous amyloid. Here the authors describe a genetic seed
                      and target system in Drosophila which may be useful for the
                      mechanistic study of seeding of amyloid in vivo.},
      cin          = {M010 / M050},
      ddc          = {500},
      cid          = {I:(DE-He78)M010-20160331 / I:(DE-He78)M050-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28894090},
      pmc          = {pmc:PMC5594032},
      doi          = {10.1038/s41467-017-00579-4},
      url          = {https://inrepo02.dkfz.de/record/128214},
}