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| Home > Publications database > Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes. > print |
| Home > Publications database > Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes. > print |
| 001 | 128225 | ||
| 005 | 20240228145537.0 | ||
| 024 | 7 | _ | |a 10.1016/j.celrep.2017.06.091 |2 doi |
| 024 | 7 | _ | |a pmid:28768202 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC5554784 |2 pmc |
| 024 | 7 | _ | |a altmetric:23349981 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-04242 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Vindry, Caroline |b 0 |
| 245 | _ | _ | |a Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes. |
| 260 | _ | _ | |a Maryland Heights, MO |c 2017 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1511258566_9859 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Pat1 RNA-binding proteins, enriched in processing bodies (P bodies), are key players in cytoplasmic 5' to 3' mRNA decay, activating decapping of mRNA in complex with the Lsm1-7 heptamer. Using co-immunoprecipitation and immunofluorescence approaches coupled with RNAi, we provide evidence for a nuclear complex of Pat1b with the Lsm2-8 heptamer, which binds to the spliceosomal U6 small nuclear RNA (snRNA). Furthermore, we establish the set of interactions connecting Pat1b/Lsm2-8/U6 snRNA/SART3 and additional U4/U6.U5 tri-small nuclear ribonucleoprotein particle (tri-snRNP) components in Cajal bodies, the site of snRNP biogenesis. RNA sequencing following Pat1b depletion revealed the preferential upregulation of mRNAs normally found in P bodies and enriched in 3' UTR AU-rich elements. Changes in >180 alternative splicing events were also observed, characterized by skipping of regulated exons with weak donor sites. Our data demonstrate the dual role of a decapping enhancer in pre-mRNA processing as well as in mRNA decay via distinct nuclear and cytoplasmic Lsm complexes. |
| 536 | _ | _ | |a 311 - Signalling pathways, cell and tumor biology (POF3-311) |0 G:(DE-HGF)POF3-311 |c POF3-311 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Marnef, Aline |b 1 |
| 700 | 1 | _ | |a Broomhead, Helen |b 2 |
| 700 | 1 | _ | |a Twyffels, Laure |b 3 |
| 700 | 1 | _ | |a Ozgur, Sevim |b 4 |
| 700 | 1 | _ | |a Stoecklin, Georg |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Llorian, Miriam |b 6 |
| 700 | 1 | _ | |a Smith, Christopher W |b 7 |
| 700 | 1 | _ | |a Mata, Juan |b 8 |
| 700 | 1 | _ | |a Weil, Dominique |b 9 |
| 700 | 1 | _ | |a Standart, Nancy |b 10 |
| 773 | _ | _ | |a 10.1016/j.celrep.2017.06.091 |g Vol. 20, no. 5, p. 1187 - 1200 |0 PERI:(DE-600)2649101-1 |n 5 |p 1187 - 1200 |t Cell reports |v 20 |y 2017 |x 2211-1247 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:128225 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 5 |6 P:(DE-HGF)0 |
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| 914 | 1 | _ | |y 2017 |
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