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| Home > Publications database > Keratin gene mutations influence the keratinocyte response to DNA damage and cytokine induced apoptosis. > print |
| 001 | 128242 | ||
| 005 | 20240228145538.0 | ||
| 024 | 7 | _ | |a 10.1007/s00403-017-1757-9 |2 doi |
| 024 | 7 | _ | |a pmid:28647894 |2 pmid |
| 024 | 7 | _ | |a 0340-3696 |2 ISSN |
| 024 | 7 | _ | |a 1432-069X |2 ISSN |
| 024 | 7 | _ | |a altmetric:21346437 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-04259 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Zupancic, Tina |b 0 |
| 245 | _ | _ | |a Keratin gene mutations influence the keratinocyte response to DNA damage and cytokine induced apoptosis. |
| 260 | _ | _ | |a Berlin |c 2017 |b Springer |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1511268547_9860 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The keratin filament cytoskeleton is vital to the normal function of epithelial cells. It provides structural support and regulates different aspects of cell metabolism. Mutations in keratins 5 and 14 cause a skin fragility disorder, epidermolysis bullosa simplex (EBS). Patients with severe EBS have an increased cumulative risk for basal cell carcinoma. In this study, we tested how keratin 5 and 14 mutant EBS patient-derived keratinocytes behave in the face of two different types of stressors that are able to induce cell death: ionizing radiation and cytokines TNF-α and TRAIL. The data point out to a substantial difference between how normal and keratin mutant keratinocytes deal with such stresses. When case of DNA damage, the ATM/Chk2-pathway is one of the two main tracks that can prevent the progression of mitosis and so allow repair. This was altered in all investigated keratin mutants with a particular down-regulation of the activated form of checkpoint kinase 2 (pChk2). Keratin mutants also appear less sensitive than normal cells to treatment with TNF-α or TRAIL, and this may be linked to the up-regulation of two pro-survival proteins, Bcl-2 and FLIP. Such changes are likely to have a profound effect on mutant keratinocytes ability to survive and withstand stress, and in theory this may be also a contributing factor to cell transformation. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Sersa, Gregor |b 1 |
| 700 | 1 | _ | |a Törmä, Hans |b 2 |
| 700 | 1 | _ | |a Lane, Ellen Birgitte |b 3 |
| 700 | 1 | _ | |a Herrmann, Harald |0 P:(DE-He78)7892a89fee19b8e3912c7423d660765d |b 4 |u dkfz |
| 700 | 1 | _ | |a Komel, Radovan |b 5 |
| 700 | 1 | _ | |a Liovic, Mirjana |0 0000-0001-8045-7868 |b 6 |
| 773 | _ | _ | |a 10.1007/s00403-017-1757-9 |g Vol. 309, no. 7, p. 587 - 593 |0 PERI:(DE-600)1458448-7 |n 7 |p 587 - 593 |t Archives of dermatological research |v 309 |y 2017 |x 1432-069X |
| 909 | C | O | |o oai:inrepo02.dkfz.de:128242 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 4 |6 P:(DE-He78)7892a89fee19b8e3912c7423d660765d |
| 913 | 1 | _ | |a DE-HGF |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-312 |2 G:(DE-HGF)POF3-300 |v Functional and structural genomics |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |b Gesundheit |
| 914 | 1 | _ | |y 2017 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b ARCH DERMATOL RES : 2015 |
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