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@ARTICLE{Schildberg:128256,
      author       = {C. W. Schildberg and M. L. Abba$^*$ and S. Merkel and A.
                      Agaimy and A. Dimmler and A. Schlabrakowski and R. Croner
                      and J. H. Leupold$^*$ and W. Hohenberger and H.
                      Allgayer$^*$},
      title        = {{G}astric cancer patients less than 50 years of age exhibit
                      significant downregulation of {E}-cadherin and {CDX}2
                      compared to older reference populations.},
      journal      = {Advances in medical sciences},
      volume       = {59},
      number       = {1},
      issn         = {1896-1126},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2017-04273},
      pages        = {142 - 146},
      year         = {2014},
      abstract     = {There is an increasing need to identify molecular markers,
                      which can be used to prognosticate patient populations in
                      gastric cancer. Whereas a significant number have been
                      identified, very few have been characterized in the context
                      of their ability to discriminate between young and old age
                      groups in which a survival difference clearly exists.In this
                      study, using immunohistochemistry, we evaluated three
                      markers with proven involvement in gastric cancer. The p53
                      tumor suppressor, the cell adhesion glycoprotein epithelial
                      cadherin (CDH1) and the caudal-related homeobox
                      transcription factor (CDX2) all of these have important
                      roles in the aetiopathogenesis and/or progression of gastric
                      cancer.After adjustments for TNM stage, tumor grade,
                      histopathological characteristics (Lauren classification),
                      we found significant differences in the expression of these
                      proteins, particularly E-cadherin and CDX2 between young and
                      elderly patients. However, these differences did not amount
                      to a significant difference in survival.This study
                      demonstrates that the protein expression of p53, CDH1 and
                      CDX2 significantly discriminates young patients with gastric
                      cancer who have a better prognostic outlook from older
                      patients, but this difference in expression does not
                      contribute to a survival benefit.},
      keywords     = {Biomarkers, Tumor (NLM Chemicals) / CDX2 Transcription
                      Factor (NLM Chemicals) / CDX2 protein, human (NLM Chemicals)
                      / Cadherins (NLM Chemicals) / Homeodomain Proteins (NLM
                      Chemicals)},
      cin          = {G360},
      ddc          = {610},
      cid          = {I:(DE-He78)G360-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24797991},
      doi          = {10.1016/j.advms.2014.03.002},
      url          = {https://inrepo02.dkfz.de/record/128256},
}