% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Boege:128312,
      author       = {Y. Boege and M. Malehmir and M. E. Healy and K. Bettermann
                      and A. Lorentzen and M. Vucur and A. K. Ahuja and F. Böhm
                      and J. C. Mertens and Y. Shimizu and L. Frick and C.
                      Remouchamps and K. Mutreja and T. Kähne and D.
                      Sundaravinayagam and M. J. Wolf and H. Rehrauer and C. Koppe
                      and T. Speicher and S. Padrissa-Altés and R. Maire and J.
                      M. Schattenberg and J.-S. Jeong and L. Liu and S.
                      Zwirner$^*$ and R. Boger and N. Hüser and R. J. Davis and
                      B. Müllhaupt and H. Moch and H. Schulze-Bergkamen and P.-A.
                      Clavien and S. Werner and L. Borsig and S. A. Luther and P.
                      J. Jost and R. Weinlich and K. Unger and A. Behrens and L.
                      Hillert and C. Dillon and M. Di Virgilio and D. Wallach and
                      E. Dejardin and L. Zender$^*$ and M. Naumann and H. Walczak
                      and D. R. Green and M. Lopes and I. Lavrik and T. Luedde and
                      M. Heikenwalder$^*$ and A. Weber},
      title        = {{A} {D}ual {R}ole of {C}aspase-8 in {T}riggering and
                      {S}ensing {P}roliferation-{A}ssociated {DNA} {D}amage, a
                      {K}ey {D}eterminant of {L}iver {C}ancer {D}evelopment.},
      journal      = {Cancer cell},
      volume       = {32},
      number       = {3},
      issn         = {1535-6108},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2017-04329},
      pages        = {342 - 359.e10},
      year         = {2017},
      abstract     = {Concomitant hepatocyte apoptosis and regeneration is a
                      hallmark of chronic liver diseases (CLDs) predisposing to
                      hepatocellular carcinoma (HCC). Here, we mechanistically
                      link caspase-8-dependent apoptosis to HCC development via
                      proliferation- and replication-associated DNA damage.
                      Proliferation-associated replication stress, DNA damage, and
                      genetic instability are detectable in CLDs before any
                      neoplastic changes occur. Accumulated levels of hepatocyte
                      apoptosis determine and predict subsequent
                      hepatocarcinogenesis. Proliferation-associated DNA damage is
                      sensed by a complex comprising caspase-8, FADD, c-FLIP, and
                      a kinase-dependent function of RIPK1. This platform requires
                      a non-apoptotic function of caspase-8, but no caspase-3 or
                      caspase-8 cleavage. It may represent a DNA damage-sensing
                      mechanism in hepatocytes that can act via JNK and subsequent
                      phosphorylation of the histone variant H2AX.},
      keywords     = {Fadd protein, mouse (NLM Chemicals) / Fas-Associated Death
                      Domain Protein (NLM Chemicals) / Histones (NLM Chemicals) /
                      Mcl1 protein, mouse (NLM Chemicals) / Myeloid Cell Leukemia
                      Sequence 1 Protein (NLM Chemicals) / Receptors, Tumor
                      Necrosis Factor, Type I (NLM Chemicals) / gamma-H2AX
                      protein, mouse (NLM Chemicals) / Receptor-Interacting
                      Protein Serine-Threonine Kinases (NLM Chemicals) / Ripk1
                      protein, mouse (NLM Chemicals) / JNK Mitogen-Activated
                      Protein Kinases (NLM Chemicals) / Caspase 8 (NLM Chemicals)},
      cin          = {V076 / F180 / L801},
      ddc          = {610},
      cid          = {I:(DE-He78)V076-20160331 / I:(DE-He78)F180-20160331 /
                      I:(DE-He78)L801-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28898696},
      pmc          = {pmc:PMC5598544},
      doi          = {10.1016/j.ccell.2017.08.010},
      url          = {https://inrepo02.dkfz.de/record/128312},
}