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| Home > Publications database > A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development. > print |
| Home > Publications database > A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development. > print |
| 001 | 128312 | ||
| 005 | 20240228145539.0 | ||
| 024 | 7 | _ | |a 10.1016/j.ccell.2017.08.010 |2 doi |
| 024 | 7 | _ | |a pmid:28898696 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC5598544 |2 pmc |
| 024 | 7 | _ | |a 1535-6108 |2 ISSN |
| 024 | 7 | _ | |a 1878-3686 |2 ISSN |
| 024 | 7 | _ | |a altmetric:25114001 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-04329 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Boege, Yannick |b 0 |
| 245 | _ | _ | |a A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development. |
| 260 | _ | _ | |a Cambridge, Mass. |c 2017 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1533801931_8713 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Concomitant hepatocyte apoptosis and regeneration is a hallmark of chronic liver diseases (CLDs) predisposing to hepatocellular carcinoma (HCC). Here, we mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and replication-associated DNA damage. Proliferation-associated replication stress, DNA damage, and genetic instability are detectable in CLDs before any neoplastic changes occur. Accumulated levels of hepatocyte apoptosis determine and predict subsequent hepatocarcinogenesis. Proliferation-associated DNA damage is sensed by a complex comprising caspase-8, FADD, c-FLIP, and a kinase-dependent function of RIPK1. This platform requires a non-apoptotic function of caspase-8, but no caspase-3 or caspase-8 cleavage. It may represent a DNA damage-sensing mechanism in hepatocytes that can act via JNK and subsequent phosphorylation of the histone variant H2AX. |
| 536 | _ | _ | |a 319H - Addenda (POF3-319H) |0 G:(DE-HGF)POF3-319H |c POF3-319H |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Fadd protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Fas-Associated Death Domain Protein |2 NLM Chemicals |
| 650 | _ | 7 | |a Histones |2 NLM Chemicals |
| 650 | _ | 7 | |a Mcl1 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Myeloid Cell Leukemia Sequence 1 Protein |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, Tumor Necrosis Factor, Type I |2 NLM Chemicals |
| 650 | _ | 7 | |a gamma-H2AX protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptor-Interacting Protein Serine-Threonine Kinases |0 EC 2.7.11.1 |2 NLM Chemicals |
| 650 | _ | 7 | |a Ripk1 protein, mouse |0 EC 2.7.11.1 |2 NLM Chemicals |
| 650 | _ | 7 | |a JNK Mitogen-Activated Protein Kinases |0 EC 2.7.11.24 |2 NLM Chemicals |
| 650 | _ | 7 | |a Caspase 8 |0 EC 3.4.22.- |2 NLM Chemicals |
| 700 | 1 | _ | |a Malehmir, Mohsen |b 1 |
| 700 | 1 | _ | |a Healy, Marc E |b 2 |
| 700 | 1 | _ | |a Bettermann, Kira |b 3 |
| 700 | 1 | _ | |a Lorentzen, Anna |b 4 |
| 700 | 1 | _ | |a Vucur, Mihael |b 5 |
| 700 | 1 | _ | |a Ahuja, Akshay K |b 6 |
| 700 | 1 | _ | |a Böhm, Friederike |b 7 |
| 700 | 1 | _ | |a Mertens, Joachim C |b 8 |
| 700 | 1 | _ | |a Shimizu, Yutaka |b 9 |
| 700 | 1 | _ | |a Frick, Lukas |b 10 |
| 700 | 1 | _ | |a Remouchamps, Caroline |b 11 |
| 700 | 1 | _ | |a Mutreja, Karun |b 12 |
| 700 | 1 | _ | |a Kähne, Thilo |b 13 |
| 700 | 1 | _ | |a Sundaravinayagam, Devakumar |b 14 |
| 700 | 1 | _ | |a Wolf, Monika J |b 15 |
| 700 | 1 | _ | |a Rehrauer, Hubert |b 16 |
| 700 | 1 | _ | |a Koppe, Christiane |b 17 |
| 700 | 1 | _ | |a Speicher, Tobias |b 18 |
| 700 | 1 | _ | |a Padrissa-Altés, Susagna |b 19 |
| 700 | 1 | _ | |a Maire, Renaud |b 20 |
| 700 | 1 | _ | |a Schattenberg, Jörn M |b 21 |
| 700 | 1 | _ | |a Jeong, Ju-Seong |b 22 |
| 700 | 1 | _ | |a Liu, Lei |b 23 |
| 700 | 1 | _ | |a Zwirner, Stefan |0 P:(DE-HGF)0 |b 24 |
| 700 | 1 | _ | |a Boger, Regina |b 25 |
| 700 | 1 | _ | |a Hüser, Norbert |b 26 |
| 700 | 1 | _ | |a Davis, Roger J |b 27 |
| 700 | 1 | _ | |a Müllhaupt, Beat |b 28 |
| 700 | 1 | _ | |a Moch, Holger |b 29 |
| 700 | 1 | _ | |a Schulze-Bergkamen, Henning |b 30 |
| 700 | 1 | _ | |a Clavien, Pierre-Alain |b 31 |
| 700 | 1 | _ | |a Werner, Sabine |b 32 |
| 700 | 1 | _ | |a Borsig, Lubor |b 33 |
| 700 | 1 | _ | |a Luther, Sanjiv A |b 34 |
| 700 | 1 | _ | |a Jost, Philipp J |b 35 |
| 700 | 1 | _ | |a Weinlich, Ricardo |b 36 |
| 700 | 1 | _ | |a Unger, Kristian |b 37 |
| 700 | 1 | _ | |a Behrens, Axel |b 38 |
| 700 | 1 | _ | |a Hillert, Laura |b 39 |
| 700 | 1 | _ | |a Dillon, Christopher |b 40 |
| 700 | 1 | _ | |a Di Virgilio, Michela |b 41 |
| 700 | 1 | _ | |a Wallach, David |b 42 |
| 700 | 1 | _ | |a Dejardin, Emmanuel |b 43 |
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| 700 | 1 | _ | |a Naumann, Michael |b 45 |
| 700 | 1 | _ | |a Walczak, Henning |b 46 |
| 700 | 1 | _ | |a Green, Douglas R |b 47 |
| 700 | 1 | _ | |a Lopes, Massimo |b 48 |
| 700 | 1 | _ | |a Lavrik, Inna |b 49 |
| 700 | 1 | _ | |a Luedde, Tom |b 50 |
| 700 | 1 | _ | |a Heikenwalder, Mathias |0 P:(DE-He78)66ed2d4ec9bc11d29b87ac006adf85e5 |b 51 |u dkfz |
| 700 | 1 | _ | |a Weber, Achim |b 52 |
| 773 | _ | _ | |a 10.1016/j.ccell.2017.08.010 |g Vol. 32, no. 3, p. 342 - 359.e10 |0 PERI:(DE-600)2074034-7 |n 3 |p 342 - 359.e10 |t Cancer cell |v 32 |y 2017 |x 1535-6108 |
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