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000128318 1001_ $$0P:(DE-He78)a4340add02b610f9dbdba2dc909cbd09$$aDelacher, Michael$$b0$$eFirst author$$udkfz
000128318 245__ $$aGenome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues.
000128318 260__ $$aNew York, NY$$bNature America Inc.$$c2017
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000128318 520__ $$aRegulatory T cells (Treg cells) perform two distinct functions: they maintain self-tolerance, and they support organ homeostasis by differentiating into specialized tissue Treg cells. We found that epigenetic modifications defined the molecular characteristics of tissue Treg cells. Tagmentation-based whole-genome bisulfite sequencing revealed more than 11,000 regions that were methylated differentially in pairwise comparisons of tissue Treg cell populations and lymphoid T cells. Similarities in the epigenetic landscape led to the identification of a common tissue Treg cell population that was present in many organs and was characterized by gain and loss of DNA methylation that included many gene sites associated with the TH2 subset of helper T cells, such as the gene encoding cytokine IL-33 receptor ST2, as well as the production of tissue-regenerative factors. Furthermore, the ST2-expressing population was dependent on the transcriptional regulator BATF and could be expanded by IL-33. Thus, tissue Treg cells integrate multiple waves of epigenetic reprogramming that define their tissue-restricted specialization.
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000128318 7001_ $$0P:(DE-HGF)0$$aImbusch, Charles D$$b1
000128318 7001_ $$0P:(DE-He78)ff4024f7bc236e7897d9c18ee19c451f$$aWeichenhan, Dieter$$b2$$udkfz
000128318 7001_ $$00000-0002-7928-299X$$aBreiling, Achim$$b3
000128318 7001_ $$00000-0003-1523-2093$$aHotz-Wagenblatt, Agnes$$b4
000128318 7001_ $$0P:(DE-He78)4d320583e7adaedcb8374d787eb6bfe5$$aTräger, Ulrike$$b5$$udkfz
000128318 7001_ $$0P:(DE-He78)24f65e08387eafe8f511b710e366fdf4$$aHofer, Ann-Cathrin$$b6$$udkfz
000128318 7001_ $$0P:(DE-He78)06354828cd2bda194bba64ffa5303d6a$$aKägebein, Danny$$b7$$udkfz
000128318 7001_ $$0P:(DE-HGF)0$$aWang, Qi$$b8
000128318 7001_ $$0P:(DE-He78)ba2c00ea5bd6b1d769de62ab5dc03849$$aFrauhammer, Felix$$b9$$udkfz
000128318 7001_ $$0P:(DE-He78)697cb039ca08f3b7e5a2a52dbf020b46$$aMallm, Jan-Philipp$$b10$$udkfz
000128318 7001_ $$0P:(DE-He78)5b10e57ed1df98e2fd31edbdeed985ba$$aBauer, Katharina$$b11$$udkfz
000128318 7001_ $$0P:(DE-He78)be4a5aeed7282c071b3ff43e9685c48c$$aHerrmann, Carl$$b12$$udkfz
000128318 7001_ $$aLang, Philipp A$$b13
000128318 7001_ $$00000-0001-5940-3101$$aBrors, Benedikt$$b14
000128318 7001_ $$0P:(DE-He78)4301875630bc997edf491c694ae1f8a9$$aPlass, Christoph$$b15$$udkfz
000128318 7001_ $$00000-0003-4261-3764$$aFeuerer, Markus$$b16$$eLast author
000128318 773__ $$0PERI:(DE-600)2026412-4$$a10.1038/ni.3799$$gVol. 18, no. 10, p. 1160 - 1172$$n10$$p1160 - 1172$$tNature immunology$$v18$$x1529-2916$$y2017
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