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@ARTICLE{Delacher:128318,
      author       = {M. Delacher$^*$ and C. D. Imbusch$^*$ and D. Weichenhan$^*$
                      and A. Breiling$^*$ and A. Hotz-Wagenblatt$^*$ and U.
                      Träger$^*$ and A.-C. Hofer$^*$ and D. Kägebein$^*$ and Q.
                      Wang$^*$ and F. Frauhammer$^*$ and J.-P. Mallm$^*$ and K.
                      Bauer$^*$ and C. Herrmann$^*$ and P. A. Lang and B.
                      Brors$^*$ and C. Plass$^*$ and M. Feuerer$^*$},
      title        = {{G}enome-wide {DNA}-methylation landscape defines
                      specialization of regulatory {T} cells in tissues.},
      journal      = {Nature immunology},
      volume       = {18},
      number       = {10},
      issn         = {1529-2916},
      address      = {New York, NY},
      publisher    = {Nature America Inc.},
      reportid     = {DKFZ-2017-04335},
      pages        = {1160 - 1172},
      year         = {2017},
      abstract     = {Regulatory T cells (Treg cells) perform two distinct
                      functions: they maintain self-tolerance, and they support
                      organ homeostasis by differentiating into specialized tissue
                      Treg cells. We found that epigenetic modifications defined
                      the molecular characteristics of tissue Treg cells.
                      Tagmentation-based whole-genome bisulfite sequencing
                      revealed more than 11,000 regions that were methylated
                      differentially in pairwise comparisons of tissue Treg cell
                      populations and lymphoid T cells. Similarities in the
                      epigenetic landscape led to the identification of a common
                      tissue Treg cell population that was present in many organs
                      and was characterized by gain and loss of DNA methylation
                      that included many gene sites associated with the TH2 subset
                      of helper T cells, such as the gene encoding cytokine IL-33
                      receptor ST2, as well as the production of
                      tissue-regenerative factors. Furthermore, the ST2-expressing
                      population was dependent on the transcriptional regulator
                      BATF and could be expanded by IL-33. Thus, tissue Treg cells
                      integrate multiple waves of epigenetic reprogramming that
                      define their tissue-restricted specialization.},
      keywords     = {Biomarkers (NLM Chemicals)},
      cin          = {D100 / C010 / W180 / G200 / B066 / B080 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)D100-20160331 / I:(DE-He78)C010-20160331 /
                      I:(DE-He78)W180-20160331 / I:(DE-He78)G200-20160331 /
                      I:(DE-He78)B066-20160331 / I:(DE-He78)B080-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28783152},
      doi          = {10.1038/ni.3799},
      url          = {https://inrepo02.dkfz.de/record/128318},
}