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@ARTICLE{ElAyadi:128320,
      author       = {M. El-Ayadi and M. Ansari and D. Sturm$^*$ and G. H. Gielen
                      and M. Warmuth-Metz and C. M. Kramm and A. O. von Bueren},
      title        = {{H}igh-grade glioma in very young children: a rare and
                      particular patient population.},
      journal      = {OncoTarget},
      volume       = {8},
      number       = {38},
      issn         = {1949-2553},
      address      = {[S.l.]},
      publisher    = {Impact Journals LLC},
      reportid     = {DKFZ-2017-04337},
      pages        = {64564- 64578},
      year         = {2017},
      abstract     = {In the past years, pediatric high-grade gliomas (HGG) have
                      been the focus of several research articles and reviews,
                      given the recent discoveries on the genetic and molecular
                      levels pointing out a clinico-biological uniqueness of the
                      pediatric population compared to their adult counterparts
                      with HGG. On the other hand, there are only scarce data
                      about HGG in very young children (below 3 years of age at
                      diagnosis) due to their relatively low incidence. However,
                      the few available data suggest further distinction of this
                      very rare subgroup from older children and adults at several
                      levels including their molecular and biological
                      characteristics, their treatment management, as well as
                      their outcome. This review summarizes and discusses the
                      current available knowledge on the epidemiological,
                      neuropathological, genetic and molecular data of this
                      subpopulation. We discuss these findings and differences
                      compared to older patients suffering from the same
                      histologic disease. In addition, we highlight the particular
                      clinical and neuro-radiological findings in this specific
                      subgroup of patients as well as their current management
                      approaches and treatment outcomes.},
      subtyp        = {Review Article},
      cin          = {B062 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28969094},
      pmc          = {pmc:PMC5610026},
      doi          = {10.18632/oncotarget.18478},
      url          = {https://inrepo02.dkfz.de/record/128320},
}