% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Sonnet:128362,
      author       = {M. Sonnet$^*$ and R. Claus and N. Becker$^*$ and M.
                      Zucknick$^*$ and J. Petersen$^*$ and D. Lipka$^*$ and C. C.
                      Oakes$^*$ and M. Andrulis and A. Lier$^*$ and M. Milsom$^*$
                      and T. Witte$^*$ and L. Gu$^*$ and S.-Z. Kim-Wanner$^*$ and
                      P. Schirmacher and M. Wulfert and N. Gattermann and M.
                      Lübbert and F. Rosenbauer and M. Rehli and L. Bullinger and
                      D. Weichenhan$^*$ and C. Plass$^*$},
      title        = {{E}arly aberrant {DNA} methylation events in a mouse model
                      of acute myeloid leukemia.},
      journal      = {Genome medicine},
      volume       = {6},
      number       = {4},
      issn         = {1756-994X},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2017-04379},
      pages        = {34},
      year         = {2014},
      abstract     = {Aberrant DNA methylation is frequently found in human
                      malignancies including acute myeloid leukemia (AML). While
                      most studies focus on later disease stages, the onset of
                      aberrant DNA methylation events and their dynamics during
                      leukemic progression are largely unknown.We screened
                      genome-wide for aberrant CpG island methylation in three
                      disease stages of a murine AML model that is driven by
                      hypomorphic expression of the hematopoietic transcription
                      factor PU.1. DNA methylation levels of selected genes were
                      correlated with methylation levels of CD34+ cells and
                      lineage negative, CD127-, c-Kit+, Sca-1+ cells; common
                      myeloid progenitors; granulocyte-macrophage progenitors; and
                      megakaryocyte-erythroid progenitors.We identified 1,184
                      hypermethylated array probes covering 762 associated genes
                      in the preleukemic stage. During disease progression, the
                      number of hypermethylated genes increased to 5,465 in the
                      late leukemic disease stage. Using publicly available data,
                      we found a significant enrichment of PU.1 binding sites in
                      the preleukemic hypermethylated genes, suggesting that
                      shortage of PU.1 makes PU.1 binding sites in the DNA
                      accessible for aberrant methylation. Many known AML
                      associated genes such as RUNX1 and HIC1 were found among the
                      preleukemic hypermethylated genes. Nine novel
                      hypermethylated genes, FZD5, FZD8, PRDM16, ROBO3, CXCL14,
                      BCOR, ITPKA, HES6 and TAL1, the latter four being potential
                      PU.1 targets, were confirmed to be hypermethylated in human
                      normal karyotype AML patients, underscoring the relevance of
                      the mouse model for human AML.Our study identified early
                      aberrantly methylated genes as potential contributors to
                      onset and progression of AML.},
      cin          = {C010 / C060 / W190 / V960 / A012 / A010},
      ddc          = {610},
      cid          = {I:(DE-He78)C010-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)W190-20160331 / I:(DE-He78)V960-20160331 /
                      I:(DE-He78)A012-20160331 / I:(DE-He78)A010-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24944583},
      pmc          = {pmc:PMC4062060},
      doi          = {10.1186/gm551},
      url          = {https://inrepo02.dkfz.de/record/128362},
}