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000128447 0247_ $$2doi$$a10.1016/j.immuni.2014.07.005
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000128447 0247_ $$2ISSN$$a1097-4180
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000128447 041__ $$aeng
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000128447 1001_ $$0P:(DE-HGF)0$$aUcar, Ahmet$$b0$$eFirst author
000128447 245__ $$aAdult thymus contains FoxN1(-) epithelial stem cells that are bipotent for medullary and cortical thymic epithelial lineages.
000128447 260__ $$a[Cambridge, Mass.]$$bCell Press$$c2014
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000128447 520__ $$aWithin the thymus, two major thymic epithelial cell (TEC) subsets-cortical and medullary TECs-provide unique structural and functional niches for T cell development and establishment of central tolerance. Both lineages are believed to originate from a common progenitor cell, yet the cellular and molecular identity of these bipotent TEC progenitors/stem cells remains ill defined. Here we identify rare stromal cells in the murine adult thymus, which under low-attachment conditions formed spheres (termed 'thymospheres'). These thymosphere-forming cells (TSFCs) displayed the stemness features of being slow cycling, self-renewing, and bipotent. TSFCs could be significantly enriched based on their distinct surface antigen phenotype. The FoxN1 transcription factor was dispensable for TSFCs maintenance in situ and for commitment to the medullary and cortical TEC lineages. In summary, this study presents the characterization of the adult thymic epithelial stem cells and demonstrates the dispensability of FoxN1 function for their stemness.
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000128447 650_7 $$2NLM Chemicals$$aAntigens, CD24
000128447 650_7 $$2NLM Chemicals$$aAntigens, Ly
000128447 650_7 $$2NLM Chemicals$$aAntigens, Neoplasm
000128447 650_7 $$2NLM Chemicals$$aCd24a protein, mouse
000128447 650_7 $$2NLM Chemicals$$aCell Adhesion Molecules
000128447 650_7 $$2NLM Chemicals$$aEpithelial Cell Adhesion Molecule
000128447 650_7 $$2NLM Chemicals$$aForkhead Transcription Factors
000128447 650_7 $$2NLM Chemicals$$aLy6a protein, mouse
000128447 650_7 $$2NLM Chemicals$$aMembrane Proteins
000128447 650_7 $$2NLM Chemicals$$aWhn protein
000128447 650_7 $$0EC 3.1.3.48$$2NLM Chemicals$$aAntigens, CD45
000128447 650_7 $$0EC 3.1.3.48$$2NLM Chemicals$$aPtprc protein, mouse
000128447 7001_ $$0P:(DE-He78)ef9d96692a18ed693fa357be2051eee4$$aUcar, Olga$$b1$$udkfz
000128447 7001_ $$0P:(DE-He78)2bcf6caeb74b07767b16f4dc850618d3$$aKlug, Paula$$b2$$udkfz
000128447 7001_ $$0P:(DE-He78)ce86d7d02a229acfaca4b63f01a1171b$$aMatt, Sonja$$b3$$udkfz
000128447 7001_ $$0P:(DE-He78)79264e5eb093c3b6fe517e4ca29da19b$$aBrunk, Fabian$$b4$$udkfz
000128447 7001_ $$0P:(DE-He78)99ae95278bd95e30462a4fb2d12026c6$$aHofmann, Thomas$$b5$$udkfz
000128447 7001_ $$0P:(DE-He78)08a57258198dcedd8ff8ac7eef40341a$$aKyewski, Bruno$$b6$$eLast author$$udkfz
000128447 773__ $$0PERI:(DE-600)2001966-X$$a10.1016/j.immuni.2014.07.005$$gVol. 41, no. 2, p. 257 - 269$$n2$$p257 - 269$$tImmunity$$v41$$x1074-7613$$y2014
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