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@ARTICLE{Ucar:128447,
      author       = {A. Ucar$^*$ and O. Ucar$^*$ and P. Klug$^*$ and S. Matt$^*$
                      and F. Brunk$^*$ and T. Hofmann$^*$ and B. Kyewski$^*$},
      title        = {{A}dult thymus contains {F}ox{N}1(-) epithelial stem cells
                      that are bipotent for medullary and cortical thymic
                      epithelial lineages.},
      journal      = {Immunity},
      volume       = {41},
      number       = {2},
      issn         = {1074-7613},
      address      = {[Cambridge, Mass.]},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2017-04463},
      pages        = {257 - 269},
      year         = {2014},
      abstract     = {Within the thymus, two major thymic epithelial cell (TEC)
                      subsets-cortical and medullary TECs-provide unique
                      structural and functional niches for T cell development and
                      establishment of central tolerance. Both lineages are
                      believed to originate from a common progenitor cell, yet the
                      cellular and molecular identity of these bipotent TEC
                      progenitors/stem cells remains ill defined. Here we identify
                      rare stromal cells in the murine adult thymus, which under
                      low-attachment conditions formed spheres (termed
                      'thymospheres'). These thymosphere-forming cells (TSFCs)
                      displayed the stemness features of being slow cycling,
                      self-renewing, and bipotent. TSFCs could be significantly
                      enriched based on their distinct surface antigen phenotype.
                      The FoxN1 transcription factor was dispensable for TSFCs
                      maintenance in situ and for commitment to the medullary and
                      cortical TEC lineages. In summary, this study presents the
                      characterization of the adult thymic epithelial stem cells
                      and demonstrates the dispensability of FoxN1 function for
                      their stemness.},
      keywords     = {Antigens, CD24 (NLM Chemicals) / Antigens, Ly (NLM
                      Chemicals) / Antigens, Neoplasm (NLM Chemicals) / Cd24a
                      protein, mouse (NLM Chemicals) / Cell Adhesion Molecules
                      (NLM Chemicals) / Epithelial Cell Adhesion Molecule (NLM
                      Chemicals) / Forkhead Transcription Factors (NLM Chemicals)
                      / Ly6a protein, mouse (NLM Chemicals) / Membrane Proteins
                      (NLM Chemicals) / Whn protein (NLM Chemicals) / Antigens,
                      CD45 (NLM Chemicals) / Ptprc protein, mouse (NLM Chemicals)},
      cin          = {D090 / A210},
      ddc          = {610},
      cid          = {I:(DE-He78)D090-20160331 / I:(DE-He78)A210-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25148026},
      pmc          = {pmc:PMC4148705},
      doi          = {10.1016/j.immuni.2014.07.005},
      url          = {https://inrepo02.dkfz.de/record/128447},
}