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@ARTICLE{Usenko:128462,
      author       = {T. Usenko and G. Chan and E. Torlakovic and U.
                      Klingmüller$^*$ and B. G. Neel},
      title        = {{L}eukemogenic {P}tpn11 allele causes defective
                      erythropoiesis in mice.},
      journal      = {PLoS one},
      volume       = {9},
      number       = {10},
      issn         = {1932-6203},
      address      = {Lawrence, Kan.},
      publisher    = {PLoS},
      reportid     = {DKFZ-2017-04478},
      pages        = {e109682 -},
      year         = {2014},
      abstract     = {Src homology 2 (SH2) domain-containing phosphatase 2
                      (SHP2), encoded by PTPN11, regulates signaling networks and
                      cell fate in many tissues. Expression of oncogenic PTPN11 in
                      the hematopoietic compartment causes myeloproliferative
                      neoplasm (MPN) in humans and mice. However, the
                      stage-specific effect(s) of mutant Ptpn11 on erythroid
                      development have remained unknown. We found that expression
                      of an activated, leukemogenic Ptpn11 allele, Ptpn11D61Y,
                      specifically in the erythroid lineage causes
                      dyserythropoiesis in mice. Ptpn11D61Y progenitors produce
                      excess cKIT+ CD71+ Ter119- cells and aberrant numbers of
                      cKITl° CD71+ erythroblasts. Mutant erythroblasts show
                      elevated activation of ERK, AKT and STAT3 in response to EPO
                      stimulation, and MEK inhibitor treatment blocks
                      Ptpn11D61Y-evoked erythroid hyperproliferation in vitro.
                      Thus, the expression of oncogenic Ptpn11 causes
                      dyserythropoiesis in a cell-autonomous manner in vivo.},
      keywords     = {Antigens, CD (NLM Chemicals) / Butadienes (NLM Chemicals) /
                      CD71 antigen (NLM Chemicals) / Nitriles (NLM Chemicals) /
                      Protein Kinase Inhibitors (NLM Chemicals) / Receptors,
                      Transferrin (NLM Chemicals) / STAT3 Transcription Factor
                      (NLM Chemicals) / Stat3 protein, mouse (NLM Chemicals) / U
                      0126 (NLM Chemicals) / Erythropoietin (NLM Chemicals) /
                      Proto-Oncogene Proteins c-kit (NLM Chemicals) /
                      Proto-Oncogene Proteins c-akt (NLM Chemicals) /
                      Extracellular Signal-Regulated MAP Kinases (NLM Chemicals) /
                      Protein Tyrosine Phosphatase, Non-Receptor Type 11 (NLM
                      Chemicals) / Ptpn11 protein, mouse (NLM Chemicals)},
      cin          = {A150},
      ddc          = {500},
      cid          = {I:(DE-He78)A150-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25289670},
      pmc          = {pmc:PMC4188809},
      doi          = {10.1371/journal.pone.0109682},
      url          = {https://inrepo02.dkfz.de/record/128462},
}