% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Wielptz:128536,
      author       = {M. O. Wielpütz$^*$ and M. Puderbach and A.
                      Kopp-Schneider$^*$ and M. Stahl and E. Fritzsching and O.
                      Sommerburg and S. Ley and M. Sumkauskaite and J.
                      Biederer$^*$ and H.-U. Kauczor and M. Eichinger and M. A.
                      Mall},
      title        = {{M}agnetic resonance imaging detects changes in structure
                      and perfusion, and response to therapy in early cystic
                      fibrosis lung disease.},
      journal      = {American journal of respiratory and critical care medicine},
      volume       = {189},
      number       = {8},
      issn         = {1535-4970},
      address      = {New York, NY},
      publisher    = {American Thoracic Society},
      reportid     = {DKFZ-2017-04552},
      pages        = {956 - 965},
      year         = {2014},
      abstract     = {Studies demonstrating early structural lung damage in
                      infants and preschool children with cystic fibrosis (CF)
                      suggest that noninvasive monitoring will be important to
                      identify patients who may benefit from early therapeutic
                      intervention. Previous studies demonstrated that magnetic
                      resonance imaging (MRI) detects structural and functional
                      abnormalities in lungs from older patients with CF without
                      radiation exposure.To evaluate the potential of MRI to
                      detect abnormal lung structure and perfusion in infants and
                      preschool children with CF, and to monitor the response to
                      therapy for pulmonary exacerbation.MRI studies were
                      performed in 50 children with CF (age, 3.1 ± 2.1 yr; range,
                      0-6 yr) in stable clinical condition (n = 40) or pulmonary
                      exacerbation before and after antibiotic treatment (n = 10),
                      and in 26 non-CF control subjects (age, 2.9 ± 1.9 yr). T1-
                      and T2-weighted sequences before and after intravenous
                      contrast and first-pass perfusion imaging were acquired, and
                      assessed on the basis of a dedicated morphofunctional
                      score.MRI demonstrated bronchial wall
                      thickening/bronchiectasis, mucus plugging, and perfusion
                      deficits from the first year of life in most stable patients
                      with CF (global score, 10.0 ± 4.0), but not in non-CF
                      control subjects (score, 0.0 ± 0.0; P < 0.001). In patients
                      with exacerbations, the global MRI score was increased to
                      18.0 ± 2.0 (P < 0.001), and was significantly reduced to
                      12.0 ± 3.0 (P < 0.05) after antibiotic therapy.MRI detected
                      abnormalities in lung structure and perfusion, and response
                      to therapy for exacerbations in infants and preschool
                      children with CF. These results support the development of
                      MRI for noninvasive monitoring and as an end point in
                      interventional trials for early CF lung disease. Clinical
                      trial registered with www.clinicaltrials.gov (NCT00760071).},
      cin          = {E010 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24564281},
      doi          = {10.1164/rccm.201309-1659OC},
      url          = {https://inrepo02.dkfz.de/record/128536},
}