%0 Journal Article
%A Wiestler, Benedikt Paul Otmar
%A Capper, David
%A Hovestadt, Volker
%A Sill, Martin
%A Jones, David
%A Hartmann, Christian
%A Felsberg, Joerg
%A Platten, Michael
%A Feiden, Wolfgang
%A Keyvani, Kathy
%A Pfister, Stefan
%A Wiestler, Otmar
%A Meyermann, Richard
%A Reifenberger, Guido
%A Pietsch, Thorsten
%A von Deimling, Andreas
%A Weller, Michael
%A Wick, Wolfgang
%T Assessing CpG island methylator phenotype, 1p/19q codeletion, and MGMT promoter methylation from epigenome-wide data in the biomarker cohort of the NOA-04 trial.
%J Neuro-Oncology
%V 16
%N 12
%@ 1523-5866
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2017-04556
%P 1630 - 1638
%D 2014
%X Molecular biomarkers including isocitrate dehydrogenase 1 or 2 (IDH1/2) mutation, 1p/19q codeletion, and O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter methylation may improve prognostication and guide treatment decisions for patients with World Health Organization (WHO) anaplastic gliomas. At present, each marker is individually tested by distinct assays. Illumina Infinium HumanMethylation450 BeadChip arrays (HM450) enable the determination of large-scale methylation profiles and genome-wide DNA copy number changes. Algorithms have been developed to detect the glioma CpG island methylator phenotype (G-CIMP) associated with IDH1/2 mutation, 1p/19q codeletion, and MGMT promoter methylation using a single assay.Here, we retrospectively investigated the diagnostic and prognostic performance of these algorithms in comparison to individual marker testing and patient outcome in the biomarker cohort (n = 115 patients) of the NOA-04 trial.Concordance for IDH and 1p/19q status was very high: In 92
%K Biomarkers (NLM Chemicals)
%K Tumor Suppressor Proteins (NLM Chemicals)
%K Isocitrate Dehydrogenase (NLM Chemicals)
%K DNA Modification Methylases (NLM Chemicals)
%K MGMT protein, human (NLM Chemicals)
%K DNA Repair Enzymes (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:25028501
%2 pmc:PMC4232086
%R 10.1093/neuonc/nou138
%U https://inrepo02.dkfz.de/record/128540