%0 Journal Article
%A Wiestler, Benedikt Paul Otmar
%A Capper, David
%A Sill, Martin
%A Jones, David
%A Hovestadt, Volker
%A Sturm, Dominik
%A Koelsche, Christian
%A Bertoni, Anna
%A Schweizer, Leonille
%A Korshunov, Andrey
%A Weiß, Elisa K
%A Schliesser, Maximilian
%A Radbruch, Alexander
%A Herold-Mende, Christel
%A Roth, Patrick
%A Unterberg, Andreas
%A Hartmann, Christian
%A Pietsch, Torsten
%A Reifenberger, Guido
%A Lichter, Peter
%A Radlwimmer, Bernhard
%A Platten, Michael
%A Pfister, Stefan
%A von Deimling, Andreas
%A Weller, Michael
%A Wick, Wolfgang
%T Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma.
%J Acta neuropathologica
%V 128
%N 4
%@ 1432-0533
%C Berlin
%I Springer
%M DKFZ-2017-04557
%P 561 - 571
%D 2014
%X The outcome of patients with anaplastic gliomas varies considerably. Whether a molecular classification of anaplastic gliomas based on large-scale genomic or epigenomic analyses is superior to histopathology for reflecting distinct biological groups, predicting outcomes and guiding therapy decisions has yet to be determined. Epigenome-wide DNA methylation analysis, using a platform which also allows the detection of copy-number aberrations, was performed in a cohort of 228 patients with anaplastic gliomas (astrocytomas, oligoastrocytomas, and oligodendrogliomas), including 115 patients of the NOA-04 trial. We further compared these tumors with a group of 55 glioblastomas. Unsupervised clustering of DNA methylation patterns revealed two main groups correlated with IDH status: CpG island methylator phenotype (CIMP) positive (77.5 
%K Nuclear Proteins (NLM Chemicals)
%K Tumor Suppressor Proteins (NLM Chemicals)
%K DNA Modification Methylases (NLM Chemicals)
%K MGMT protein, human (NLM Chemicals)
%K Telomerase (NLM Chemicals)
%K DNA Helicases (NLM Chemicals)
%K ATRX protein, human (NLM Chemicals)
%K DNA Repair Enzymes (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:25008768
%R 10.1007/s00401-014-1315-x
%U https://inrepo02.dkfz.de/record/128541