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@ARTICLE{Wolf:128559,
      author       = {M. B. Wolf$^*$ and F. Murray and K. Kilk and J. Hillengass
                      and S. Delorme$^*$ and C. Heiss$^*$ and K. Neben and H.
                      Goldschmidt and H.-U. Kauczor and M.-A. Weber},
      title        = {{S}ensitivity of whole-body {CT} and {MRI} versus
                      projection radiography in the detection of osteolyses in
                      patients with monoclonal plasma cell disease.},
      journal      = {European journal of radiology},
      volume       = {83},
      number       = {7},
      issn         = {0720-048X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2017-04575},
      pages        = {1222 - 1230},
      year         = {2014},
      abstract     = {To compare sensitivity of whole-body Computed Tomography
                      (wb-CT) and whole-body Magnetic Resonance Imaging (wb-MRI)
                      with Projection Radiography (PR) regarding each method's
                      ability to detect osteolyses in patients with monoclonal
                      plasma cell disease.The bone status of 171 patients was
                      evaluated. All patients presented with multiple myeloma (MM)
                      of all stages, monoclonal gammopathy of unknown significance
                      (MGUS) or solitary plasmacytoma. Two groups were formed.
                      Group A consisted of 52 patients (26 females, 26 males) with
                      an average age of 62 years (range, 45-89 years) who
                      received, both, PR and wb-CT as part of their diagnostic
                      work-up. Group B comprised 119 patients (58 females, 61
                      males) averaging 57 years of age (range, 20-80 years) who
                      received, both, PR and wb-MRI. Two experienced radiologists
                      were blinded regarding the disease status and assessed the
                      number and location of osteolyses in consensus. A
                      distinction was made between axial and extra-axial
                      lesions.In group A, wb-CT revealed osteolyses in 12 patients
                      $(23\%)$ that were not detected in PR. CT was superior in
                      detecting lesions in patients with osteopenia and
                      osteoporosis. Compared with PR, wb-CT was significantly more
                      sensitive in detecting osteolyses than PR (p<0.001). This
                      was particularly true for axial lesions. Additionally, CT
                      revealed clinically relevant incidental findings in 33
                      patients $(63\%).$ In group B, wb-MRI revealed lesions in 19
                      patients $(16\%)$ that were not detected in PR. All lesions
                      detected by PR were also detected by wb-MRI and wb-CT.
                      Wb-MRI and wb-CT are each superior to PR in detecting axial
                      lesions.Wb-CT can detect $23\%$ more focal lesions than PR,
                      especially in the axial skeleton. Therefore, this imaging
                      method should be preferred over PR in the diagnostic work-up
                      and staging of patients with monoclonal plasma cell
                      disease.},
      cin          = {E010 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24793843},
      doi          = {10.1016/j.ejrad.2014.02.008},
      url          = {https://inrepo02.dkfz.de/record/128559},
}