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@ARTICLE{Gross:128627,
      author       = {J. P. Gross and J. Nattenmüller and S. Hemmer and D.
                      Tichy$^*$ and J. Krzykalla$^*$ and H. Goldschmidt and U.
                      Bertsch and S. Delorme$^*$ and H.-U. Kauczor and J.
                      Hillengass$^*$ and M. Merz$^*$},
      title        = {{B}ody fat composition as predictive factor for treatment
                      response in patients with newly diagnosed multiple myeloma -
                      subgroup analysis of the prospective {GMMG} {MM}5 trial.},
      journal      = {OncoTarget},
      volume       = {8},
      number       = {40},
      issn         = {1949-2553},
      address      = {[S.l.]},
      publisher    = {Impact Journals LLC},
      reportid     = {DKFZ-2017-04643},
      pages        = {68460-68471},
      year         = {2017},
      abstract     = {Obesity is a well-known risk factor for malignant tumors
                      and increased body mass index (BMI) is correlated to the
                      risk of developing multiple myeloma (MM). The correlation of
                      body fat composition with disease activity, adverse events
                      and treatment response of MM patients has not been
                      investigated yet.A subgroup of 108 patients from a single
                      institution enrolled in the prospective GMMG-MM5 trial, who
                      received a whole-body low-dose computed tomography (WBLDCT)
                      before induction therapy, were included in this study. Body
                      fat composition was measured in WBLDCT for each patient,
                      divided in the compartments abdomen, pelvis, thigh and
                      further categorized in subcutaneous (SAT) and visceral
                      adipose tissue (VAT). The correlation of these parameters
                      with disease activity (M protein, plasma cell count, LDH,
                      CRAB-criteria), adverse cytogenetics, adverse events and
                      treatment response were evaluated.Significant reciprocal
                      correlation was found between adverse cytogenetics and VAT
                      of the abdomen and pelvis, respectively (gain 1q21: p=0.009
                      and p=0.021; t(4;14): p=0.038 and p=0.042). No correlation
                      of VAT or SAT with adverse events was observed. Significant
                      reciprocal correlation was observed between abdominal
                      (p=0.03) and pelvic (p=0.035) VAT and treatment response.
                      Abdominal VAT remains significant (p=0.034) independently of
                      revised ISS stage and treatment. The BMI did not show a
                      significant correlation with treatment response or
                      investigated cytogenetics.Based on the clinically relevant
                      difference in treatment outcome depending on VAT and SAT,
                      excessive body fat of abdomen and pelvis might be a
                      predictive factor for poor treatment response. Further
                      influences in this context should be considered as well,
                      e.g. chemotherapy dosing and body fat metabolism. Further
                      studies are necessary to investigate this hypothesis.},
      cin          = {C060 / E010},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331 / I:(DE-He78)E010-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28978130},
      pmc          = {pmc:PMC5620270},
      doi          = {10.18632/oncotarget.19536},
      url          = {https://inrepo02.dkfz.de/record/128627},
}