TY  - JOUR
AU  - Radujkovic, Aleksandar
AU  - Kordelas, Lambros
AU  - Krzykalla, Julia
AU  - Beelen, Dietrich W
AU  - Benner, Axel
AU  - Lehners, Nicola
AU  - Schmidt, Katharina
AU  - Dreger, Peter
AU  - Luft, Thomas
TI  - Pretransplant Vitamin D Deficiency Is Associated With Higher Relapse Rates in Patients Allografted for Myeloid Malignancies.
JO  - Journal of clinical oncology
VL  - 35
IS  - 27
SN  - 1527-7755
CY  - Alexandria, Va.
PB  - American Society of Clinical Oncology
M1  - DKFZ-2017-04664
SP  - 3143 - 3152
PY  - 2017
AB  - Purpose Vitamin D (VitD) deficiency is common in patients with hematologic malignancies undergoing allogeneic transplantation (alloSCT), but its prognostic relevance is unclear. Patients and Methods The impact of pretransplant VitD status on overall survival, relapse mortality, and nonrelapse mortality was investigated retrospectively in a cohort of 492 patients undergoing alloSCT at our center from 2002 to 2013. VitD deficiency was defined as a serum level of 25-hydroxyvitamin D3 < 20 ng/mL (equivalent to < 50 nM) before alloSCT and was assessed using accredited laboratory methods and a standard chemiluminescent immunoassay. Results were validated in an independent cohort of 398 patients diagnosed with myeloid malignancies. Results A total of 396 (80
LB  - PUB:(DE-HGF)16
C6  - pmid:28771378
DO  - DOI:10.1200/JCO.2017.73.0085
UR  - https://inrepo02.dkfz.de/record/128648
ER  -