000128664 001__ 128664
000128664 005__ 20240228145545.0
000128664 0247_ $$2doi$$a10.1016/j.mri.2017.05.001
000128664 0247_ $$2pmid$$apmid:28526431
000128664 0247_ $$2pmc$$apmc:PMC5581699
000128664 0247_ $$2ISSN$$a0730-725X
000128664 0247_ $$2ISSN$$a1873-5894
000128664 037__ $$aDKFZ-2017-04680
000128664 041__ $$aeng
000128664 082__ $$a610
000128664 1001_ $$aZu, Zhongliang$$b0
000128664 245__ $$aMeasurement of APT using a combined CERT-AREX approach with varying duty cycles.
000128664 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2017
000128664 3367_ $$2DRIVER$$aarticle
000128664 3367_ $$2DataCite$$aOutput Types/Journal article
000128664 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1511268456_9921
000128664 3367_ $$2BibTeX$$aARTICLE
000128664 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000128664 3367_ $$00$$2EndNote$$aJournal Article
000128664 520__ $$aThe goal is to develop an imaging method where contrast reflects amide-water magnetization exchange, with minimal signal contributions from other sources. Conventional chemical exchange saturation transfer (CEST) imaging of amides (often called amide proton transfer, or APT, and quantified by the metric MTRasym) is confounded by several factors unrelated to amides, such as aliphatic protons, water relaxation, and macromolecular magnetization transfer. In this work, we examined the effects of combining our previous chemical exchange rotation (CERT) approach with the non-linear AREX method while using different duty cycles (DC) for the label and reference scans. The dependencies of this approach, named AREXdouble,vdc, on tissue parameters, including T1, T2, semi-solid component concentration (fm), relayed nuclear Overhauser enhancement (rNOE), and nearby amines, were studied through numerical simulations and control sample experiments at 9.4T and 1μT irradiation. Simulations and experiments show that AREXdouble,vdc is sensitive to amide-water exchange effects, but is relatively insensitive to T1, T2, fm, nearby amine, and distant aliphatic protons, while the conventional metric MTRasym, as well as several other APT imaging methods, are significantly affected by at least some of these confounding factors.
000128664 536__ $$0G:(DE-HGF)POF3-315$$a315 - Imaging and radiooncology (POF3-315)$$cPOF3-315$$fPOF III$$x0
000128664 588__ $$aDataset connected to CrossRef, PubMed,
000128664 7001_ $$aLi, Hua$$b1
000128664 7001_ $$aXu, Junzhong$$b2
000128664 7001_ $$aZhang, Xiao-Yong$$b3
000128664 7001_ $$0P:(DE-He78)db923d831c5fe9b5e8fab7794dd45c44$$aZaiss, Moritz$$b4$$udkfz
000128664 7001_ $$aLi, Ke$$b5
000128664 7001_ $$aDoes, Mark D$$b6
000128664 7001_ $$aGore, John C$$b7
000128664 7001_ $$aGochberg, Daniel F$$b8
000128664 773__ $$0PERI:(DE-600)1500646-3$$a10.1016/j.mri.2017.05.001$$gVol. 42, p. 22 - 31$$p22 - 31$$tMagnetic resonance imaging$$v42$$x0730-725X$$y2017
000128664 909CO $$ooai:inrepo02.dkfz.de:128664$$pVDB
000128664 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)db923d831c5fe9b5e8fab7794dd45c44$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000128664 9131_ $$0G:(DE-HGF)POF3-315$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vImaging and radiooncology$$x0
000128664 9141_ $$y2017
000128664 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000128664 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000128664 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000128664 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bMAGN RESON IMAGING : 2015
000128664 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000128664 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000128664 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000128664 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000128664 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000128664 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000128664 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000128664 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000128664 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000128664 9201_ $$0I:(DE-He78)E020-20160331$$kE020$$lMedizinische Physik in der Radiologie$$x0
000128664 980__ $$ajournal
000128664 980__ $$aVDB
000128664 980__ $$aI:(DE-He78)E020-20160331
000128664 980__ $$aUNRESTRICTED