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@ARTICLE{Zu:128664,
      author       = {Z. Zu and H. Li and J. Xu and X.-Y. Zhang and M. Zaiss$^*$
                      and K. Li and M. D. Does and J. C. Gore and D. F. Gochberg},
      title        = {{M}easurement of {APT} using a combined {CERT}-{AREX}
                      approach with varying duty cycles.},
      journal      = {Magnetic resonance imaging},
      volume       = {42},
      issn         = {0730-725X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2017-04680},
      pages        = {22 - 31},
      year         = {2017},
      abstract     = {The goal is to develop an imaging method where contrast
                      reflects amide-water magnetization exchange, with minimal
                      signal contributions from other sources. Conventional
                      chemical exchange saturation transfer (CEST) imaging of
                      amides (often called amide proton transfer, or APT, and
                      quantified by the metric MTRasym) is confounded by several
                      factors unrelated to amides, such as aliphatic protons,
                      water relaxation, and macromolecular magnetization transfer.
                      In this work, we examined the effects of combining our
                      previous chemical exchange rotation (CERT) approach with the
                      non-linear AREX method while using different duty cycles
                      (DC) for the label and reference scans. The dependencies of
                      this approach, named AREXdouble,vdc, on tissue parameters,
                      including T1, T2, semi-solid component concentration (fm),
                      relayed nuclear Overhauser enhancement (rNOE), and nearby
                      amines, were studied through numerical simulations and
                      control sample experiments at 9.4T and 1μT irradiation.
                      Simulations and experiments show that AREXdouble,vdc is
                      sensitive to amide-water exchange effects, but is relatively
                      insensitive to T1, T2, fm, nearby amine, and distant
                      aliphatic protons, while the conventional metric MTRasym, as
                      well as several other APT imaging methods, are significantly
                      affected by at least some of these confounding factors.},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28526431},
      pmc          = {pmc:PMC5581699},
      doi          = {10.1016/j.mri.2017.05.001},
      url          = {https://inrepo02.dkfz.de/record/128664},
}