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| Home > Publications database > Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations. > print |
| 001 | 128679 | ||
| 005 | 20240228145545.0 | ||
| 024 | 7 | _ | |a 10.1182/blood-2017-01-765107 |2 doi |
| 024 | 7 | _ | |a pmid:28801450 |2 pmid |
| 024 | 7 | _ | |a 0006-4971 |2 ISSN |
| 024 | 7 | _ | |a 1528-0020 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2017-04694 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Durham, Benjamin H |b 0 |
| 245 | _ | _ | |a Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations. |
| 260 | _ | _ | |a Stanford, Calif. |c 2017 |b HighWire Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1660653170_9237 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Classical hairy cell leukemia (cHCL) is characterized by a near 100% frequency of the BRAFV600E mutation, whereas ∼30% of variant HCLs (vHCLs) have MAP2K1 mutations. However, recurrent genetic alterations cooperating with BRAFV600E or MAP2K1 mutations in HCL, as well as those in MAP2K1 wild-type vHCL, are not well defined. We therefore performed deep targeted mutational and copy number analysis of cHCL (n = 53) and vHCL (n = 8). The most common genetic alteration in cHCL apart from BRAFV600E was heterozygous loss of chromosome 7q, the minimally deleted region of which targeted wild-type BRAF, subdividing cHCL into those hemizygous versus heterozygous for the BRAFV600E mutation. In addition to CDKN1B mutations in cHCL, recurrent inactivating mutations in KMT2C (MLL3) were identified in 15% and 25% of cHCLs and vHCLs, respectively. Moreover, 13% of vHCLs harbored predicted activating mutations in CCND3 A change-of-function mutation in the splicing factor U2AF1 was also present in 13% of vHCLs. Genomic analysis of de novo vemurafenib-resistant cHCL identified a novel gain-of-function mutation in IRS1 and losses of NF1 and NF2, each of which contributed to resistance. These data provide further insight into the genetic bases of cHCL and vHCL and mechanisms of RAF inhibitor resistance encountered clinically. |
| 536 | _ | _ | |a 317 - Translational cancer research (POF3-317) |0 G:(DE-HGF)POF3-317 |c POF3-317 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Antineoplastic Agents |2 NLM Chemicals |
| 650 | _ | 7 | |a CCND3 protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a CDKN1B protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Cyclin D3 |2 NLM Chemicals |
| 650 | _ | 7 | |a DNA-Binding Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Indoles |2 NLM Chemicals |
| 650 | _ | 7 | |a MLL3 protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Splicing Factor U2AF |2 NLM Chemicals |
| 650 | _ | 7 | |a Sulfonamides |2 NLM Chemicals |
| 650 | _ | 7 | |a U2AF1 protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Cyclin-Dependent Kinase Inhibitor p27 |0 147604-94-2 |2 NLM Chemicals |
| 650 | _ | 7 | |a vemurafenib |0 207SMY3FQT |2 NLM Chemicals |
| 650 | _ | 7 | |a Proto-Oncogene Proteins B-raf |0 EC 2.7.11.1 |2 NLM Chemicals |
| 650 | _ | 7 | |a MAP Kinase Kinase 1 |0 EC 2.7.12.2 |2 NLM Chemicals |
| 650 | _ | 7 | |a MAP2K1 protein, human |0 EC 2.7.12.2 |2 NLM Chemicals |
| 700 | 1 | _ | |a Getta, Bartlomiej |b 1 |
| 700 | 1 | _ | |a Dietrich, Sascha |0 P:(DE-He78)6333b389d0abc96ef7f2f6e049a8f8c4 |b 2 |u dkfz |
| 700 | 1 | _ | |a Taylor, Justin |b 3 |
| 700 | 1 | _ | |a Won, Helen |b 4 |
| 700 | 1 | _ | |a Bogenberger, James M |b 5 |
| 700 | 1 | _ | |a Scott, Sasinya |b 6 |
| 700 | 1 | _ | |a Kim, Eunhee |b 7 |
| 700 | 1 | _ | |a Chung, Young Rock |b 8 |
| 700 | 1 | _ | |a Chung, Stephen S |b 9 |
| 700 | 1 | _ | |a Hüllein, Jennifer |0 P:(DE-He78)c9be4ab60d1090c3d315a2ca6905e9ea |b 10 |u dkfz |
| 700 | 1 | _ | |a Walther, Tatjana |0 P:(DE-He78)e8feda17d03b95bda3e8717e79dc07b8 |b 11 |u dkfz |
| 700 | 1 | _ | |a Wang, Lu |b 12 |
| 700 | 1 | _ | |a Lu, Sydney X |b 13 |
| 700 | 1 | _ | |a Oakes, Christopher C |b 14 |
| 700 | 1 | _ | |a Tibes, Raoul |b 15 |
| 700 | 1 | _ | |a Haferlach, Torsten |b 16 |
| 700 | 1 | _ | |a Taylor, Barry S |b 17 |
| 700 | 1 | _ | |a Tallman, Martin S |b 18 |
| 700 | 1 | _ | |a Berger, Michael F |b 19 |
| 700 | 1 | _ | |a Park, Jae H |b 20 |
| 700 | 1 | _ | |a Zenz, Thorsten |0 P:(DE-He78)f3d5f16b49eb47520def635be98d5576 |b 21 |u dkfz |
| 700 | 1 | _ | |a Abdel-Wahab, Omar |0 0000-0002-3907-6171 |b 22 |
| 773 | _ | _ | |a 10.1182/blood-2017-01-765107 |g Vol. 130, no. 14, p. blood-2017-01-765107 - |0 PERI:(DE-600)1468538-3 |n 14 |p 1644-1648 |t Blood |v 130 |y 2017 |x 1528-0020 |
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