TY  - JOUR
AU  - Keil, V. C.
AU  - Warmuth-Metz, M.
AU  - Reh, C.
AU  - Enkirch, S. J.
AU  - Reinert, C.
AU  - Beier, D.
AU  - Jones, D. T. W.
AU  - Pietsch, T.
AU  - Schild, H. H.
AU  - Hattingen, E.
AU  - Hau, P.
TI  - Imaging Biomarkers for Adult Medulloblastomas: Genetic Entities May Be Identified by Their MR Imaging Radiophenotype.
JO  - American journal of neuroradiology
VL  - 38
IS  - 10
SN  - 1936-959X
CY  - Oak Brook, Ill.
PB  - Soc.
M1  - DKFZ-2017-04700
SP  - 1892 - 1898
PY  - 2017
AB  - The occurrence of medulloblastomas in adults is rare; nevertheless, these tumors can be subdivided into genetic and histologic entities each having distinct prognoses. This study aimed to identify MR imaging biomarkers to classify these entities and to uncover differences in MR imaging biomarkers identified in pediatric medulloblastomas.Eligible preoperative MRIs from 28 patients (11 women; 22-53 years of age) of the Multicenter Pilot-study for the Therapy of Medulloblastoma of Adults (NOA-7) cohort were assessed by 3 experienced neuroradiologists. Lesions and perifocal edema were volumetrized and multiparametrically evaluated for classic morphologic characteristics, location, hydrocephalus, and Chang criteria. To identify MR imaging biomarkers, we correlated genetic entities sonic hedgehog (SHH) TP53 wild type, wingless (WNT), and non-WNT/non-SHH medulloblastomas (in adults, Group 4), and histologic entities were correlated with the imaging criteria. These MR imaging biomarkers were compared with corresponding data from a pediatric study.There were 19 SHH TP53 wild type (69
LB  - PUB:(DE-HGF)16
C6  - pmid:28798218
DO  - DOI:10.3174/ajnr.A5313
UR  - https://inrepo02.dkfz.de/record/128685
ER  -