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@ARTICLE{Zimmer:128704,
      author       = {P. Zimmer$^*$ and W. Bloch and M. Kieven and L. Lövenich
                      and J. Lehmann and M. Holthaus and S. Theurich and A.
                      Schenk},
      title        = {{S}erotonin {S}hapes the {M}igratory {P}otential of {NK}
                      {C}ells - {A}n in vitro {A}pproach.},
      journal      = {International journal of sports medicine},
      volume       = {38},
      number       = {11},
      issn         = {0172-4622},
      address      = {Stuttgart [u.a.]},
      publisher    = {Thieme47474},
      reportid     = {DKFZ-2017-04719},
      pages        = {857-863},
      year         = {2017},
      abstract     = {Increased serotonin (5-HT) levels have been shown to
                      influence natural killer cell (NK cell) function. Acute
                      exercise mobilizes and activates NK cells and further
                      increases serum 5-HT concentrations in a dose-dependent
                      manner. The aim of this study was to investigate the impact
                      of different serum 5-HT concentrations on NK cell migratory
                      potential and cytotoxicity. The human NK cell line KHYG-1
                      was assigned to 4 conditions, including 3 physiological
                      concentrations of 5-HT (100, 130 or 170 µg/l 5-HT) and
                      one control condition. NK cells were analyzed regarding
                      cytotoxicity, migratory potential and expression of adhesion
                      molecules. No treatment effect on NK cell cytotoxicity and
                      expression of integrin subunits was detected. Migratory
                      potential was increased in a dose dependent manner,
                      indicating the highest protease activity in cells that were
                      incubated with 170 µg/l 5-HT (170 µg/l vs. control,
                      p<0.001, 170 µg/l vs. 100 µg/l, p<0.001; 170 µg/l
                      vs. 130 µg/l, p=0.003; 130 µg/l vs. control, p<0.001,
                      130 µg/l vs. 100 µg/l, p<0.001). These results suggest
                      that elevated 5-HT serum levels play a mediating role in NK
                      cell function. As exercise has been shown to be involved in
                      NK cell mobilization and redistribution, the influence of
                      5-HT should be investigated in ex vivo and in vivo
                      experiments.},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28783845},
      doi          = {10.1055/s-0043-113042},
      url          = {https://inrepo02.dkfz.de/record/128704},
}