TY  - JOUR
AU  - Hillengass, Jens
AU  - Ritsch, Judith
AU  - Merz, Maximilian
AU  - Wagner, Barbara
AU  - Kunz, Christina
AU  - Hielscher, Thomas
AU  - Laue, Hendrik
AU  - Bäuerle, Tobias
AU  - Zechmann, Christian M
AU  - Ho, Anthony D
AU  - Schlemmer, Heinz-Peter
AU  - Goldschmidt, Hartmut
AU  - Moehler, Thomas M
AU  - Delorme, Stefan
TI  - Increased microcirculation detected by dynamic contrast-enhanced magnetic resonance imaging is of prognostic significance in asymptomatic myeloma.
JO  - British journal of haematology
VL  - 174
IS  - 1
SN  - 0007-1048
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell55962
M1  - DKFZ-2017-04796
SP  - 127 - 135
PY  - 2016
AB  - This prospective study aimed to investigate the prognostic significance of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) as a non-invasive imaging technique delivering the quantitative parameters amplitude A (reflecting blood volume) and exchange rate constant kep (reflecting vascular permeability) in patients with asymptomatic monoclonal plasma cell diseases. We analysed DCE-MRI parameters in 33 healthy controls and 148 patients with monoclonal gammopathy of undetermined significance (MGUS) or smouldering multiple myeloma (SMM) according to the 2003 IMWG guidelines. All individuals underwent standardized DCE-MRI of the lumbar spine. Regions of interest were drawn manually on T1-weighted images encompassing the bone marrow of each of the 5 lumbar vertebrae sparing the vertebral vessel. Prognostic significance for median of amplitude A (univariate: P < 0·001, hazard ratio (HR) 2·42, multivariate P = 0·02, HR 2·7) and exchange rate constant kep (univariate P = 0·03, HR 1·92, multivariate P = 0·46, HR 1·5) for time to progression of 79 patients with SMM was found. Patients with amplitude A above the optimal cut-off point of 0·89 arbitrary units had a 2-year progression rate into symptomatic disease of 80
LB  - PUB:(DE-HGF)16
C6  - pmid:26991959
DO  - DOI:10.1111/bjh.14038
UR  - https://inrepo02.dkfz.de/record/128781
ER  -