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@ARTICLE{Hillengass:128781,
      author       = {J. Hillengass$^*$ and J. Ritsch and M. Merz$^*$ and B.
                      Wagner and C. Kunz$^*$ and T. Hielscher$^*$ and H. Laue and
                      T. Bäuerle and C. M. Zechmann and A. D. Ho and H.-P.
                      Schlemmer$^*$ and H. Goldschmidt and T. M. Moehler and S.
                      Delorme$^*$},
      title        = {{I}ncreased microcirculation detected by dynamic
                      contrast-enhanced magnetic resonance imaging is of
                      prognostic significance in asymptomatic myeloma.},
      journal      = {British journal of haematology},
      volume       = {174},
      number       = {1},
      issn         = {0007-1048},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell55962},
      reportid     = {DKFZ-2017-04796},
      pages        = {127 - 135},
      year         = {2016},
      abstract     = {This prospective study aimed to investigate the prognostic
                      significance of dynamic contrast enhanced magnetic resonance
                      imaging (DCE-MRI) as a non-invasive imaging technique
                      delivering the quantitative parameters amplitude A
                      (reflecting blood volume) and exchange rate constant kep
                      (reflecting vascular permeability) in patients with
                      asymptomatic monoclonal plasma cell diseases. We analysed
                      DCE-MRI parameters in 33 healthy controls and 148 patients
                      with monoclonal gammopathy of undetermined significance
                      (MGUS) or smouldering multiple myeloma (SMM) according to
                      the 2003 IMWG guidelines. All individuals underwent
                      standardized DCE-MRI of the lumbar spine. Regions of
                      interest were drawn manually on T1-weighted images
                      encompassing the bone marrow of each of the 5 lumbar
                      vertebrae sparing the vertebral vessel. Prognostic
                      significance for median of amplitude A (univariate:
                      P < 0·001, hazard ratio (HR) 2·42, multivariate
                      P = 0·02, HR 2·7) and exchange rate constant kep
                      (univariate P = 0·03, HR 1·92, multivariate P = 0·46,
                      HR 1·5) for time to progression of 79 patients with SMM was
                      found. Patients with amplitude A above the optimal cut-off
                      point of 0·89 arbitrary units had a 2-year progression rate
                      into symptomatic disease of $80\%.$ In conclusion, DCE-MRI
                      parameters are of prognostic significance for time to
                      progression in patients with SMM but not in individuals with
                      MGUS.},
      cin          = {E010 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26991959},
      doi          = {10.1111/bjh.14038},
      url          = {https://inrepo02.dkfz.de/record/128781},
}