TY  - JOUR
AU  - Hütter-Krönke, Marie-Luise
AU  - Benner, Axel
AU  - Döhner, Konstanze
AU  - Krauter, Jürgen
AU  - Weber, Daniela
AU  - Moessner, Margit
AU  - Köhne, Claus-Henning
AU  - Horst, Heinz A
AU  - Schmidt-Wolf, Ingo G H
AU  - Rummel, Mathias
AU  - Götze, Katharina
AU  - Koller, Elisabeth
AU  - Petzer, Andreas L
AU  - Salwender, Hans
AU  - Fiedler, Walter
AU  - Kirchen, Heinz
AU  - Haase, Detlef
AU  - Kremers, Stephan
AU  - Theobald, Matthias
AU  - Matzdorff, Axel C
AU  - Ganser, Arnold
AU  - Döhner, Hartmut
AU  - Schlenk, Richard F
TI  - Salvage therapy with high-dose cytarabine and mitoxantrone in combination with all-trans retinoic acid and gemtuzumab ozogamicin in acute myeloid leukemia refractory to first induction therapy.
JO  - Haematologica
VL  - 101
IS  - 7
SN  - 1592-8721
CY  - Pavia
PB  - Ferrata Storti Foundation
M1  - DKFZ-2017-04829
SP  - 839 - 845
PY  - 2016
AB  - Outcome of patients with primary refractory acute myeloid leukemia remains unsatisfactory. We conducted a prospective phase II clinical trial with gemtuzumab ozogamicin (3 mg/m(2) intravenously on day 1), all-trans retinoic acid (45 mg/m(2) orally on days 4-6 and 15 mg/m(2) orally on days 7-28), high-dose cytarabine (3 g/m(2)/12 h intravenously on days 1-3) and mitoxantrone (12 mg/m(2) intravenously on days 2-3) in 93 patients aged 18-60 years refractory to one cycle of induction therapy. Primary end point of the study was response to therapy; secondary end points included evaluation of toxicities, in particular, rate of sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation. Complete remission or complete remission with incomplete blood count recovery was achieved in 47 (51
KW  - Aminoglycosides (NLM Chemicals)
KW  - Antibodies, Monoclonal, Humanized (NLM Chemicals)
KW  - Cytarabine (NLM Chemicals)
KW  - Tretinoin (NLM Chemicals)
KW  - gemtuzumab (NLM Chemicals)
KW  - Mitoxantrone (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:27036160
C2  - pmc:PMC5004463
DO  - DOI:10.3324/haematol.2015.141622
UR  - https://inrepo02.dkfz.de/record/128816
ER  -