000128879 001__ 128879
000128879 005__ 20240228143354.0
000128879 0247_ $$2doi$$a10.1016/j.jneuroim.2016.05.014
000128879 0247_ $$2pmid$$apmid:27397084
000128879 0247_ $$2ISSN$$a0165-5728
000128879 0247_ $$2ISSN$$a1872-8421
000128879 0247_ $$2altmetric$$aaltmetric:8124641
000128879 037__ $$aDKFZ-2017-04892
000128879 041__ $$aeng
000128879 082__ $$a610
000128879 1001_ $$0P:(DE-He78)1f4e474ebc02bd0cf008f2b9098525d2$$aKeil, Melanie$$b0$$eFirst author$$udkfz
000128879 245__ $$aGeneral control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation.
000128879 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2016
000128879 3367_ $$2DRIVER$$aarticle
000128879 3367_ $$2DataCite$$aOutput Types/Journal article
000128879 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1524467266_26994
000128879 3367_ $$2BibTeX$$aARTICLE
000128879 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000128879 3367_ $$00$$2EndNote$$aJournal Article
000128879 520__ $$aRelapsing-remitting multiple sclerosis (MS)(2) is characterized by phases of acute neuroinflammation followed by spontaneous remission. Termination of inflammation is accompanied by an influx of regulatory T cells (Tregs).(3) The molecular mechanisms responsible for directing Tregs into the inflamed CNS tissue, however, are incompletely understood. In an MS mouse model we show that the stress kinase general control non-derepressible 2 (GCN2),(4) expressed in T cells, contributes to the resolution of autoimmune neuroinflammation. Failure to recover from acute inflammation was associated with reduced frequencies of CNS-infiltrating Tregs. GCN2 deficient Tregs displayed impaired migration to a CCL2 gradient. These data suggest an important contribution of the T cell stress response to the resolution of autoimmune neuroinflammation.
000128879 536__ $$0G:(DE-HGF)POF3-317$$a317 - Translational cancer research (POF3-317)$$cPOF3-317$$fPOF III$$x0
000128879 588__ $$aDataset connected to CrossRef, PubMed,
000128879 650_7 $$2NLM Chemicals$$aAnnexin A5
000128879 650_7 $$2NLM Chemicals$$aCytokines
000128879 650_7 $$2NLM Chemicals$$aMyelin-Oligodendrocyte Glycoprotein
000128879 650_7 $$2NLM Chemicals$$aPeptide Fragments
000128879 650_7 $$2NLM Chemicals$$amyelin oligodendrocyte glycoprotein (35-55)
000128879 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aEif2ak4 protein, mouse
000128879 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aProtein-Serine-Threonine Kinases
000128879 7001_ $$0P:(DE-He78)1f1efec9a95d1778031cb6f0b19ba58b$$aSonner, Jana$$b1$$udkfz
000128879 7001_ $$0P:(DE-He78)22a10e47ef85d2b98a12b21a7f332e56$$aLanz, Tobias$$b2$$udkfz
000128879 7001_ $$0P:(DE-He78)19ad2213f94e3900fa9a1b02f36b965a$$aOezen, Iris$$b3$$udkfz
000128879 7001_ $$0P:(DE-He78)e681100c540b628a2bdbd48772b4fb50$$aBunse, Theresa$$b4$$udkfz
000128879 7001_ $$aBittner, Stefan$$b5
000128879 7001_ $$aMeyer, Hannah V$$b6
000128879 7001_ $$aMeuth, Sven G$$b7
000128879 7001_ $$0P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aWick, Wolfgang$$b8$$udkfz
000128879 7001_ $$0P:(DE-He78)5ef8651b0f857b9c640aa5b1498c43b5$$aPlatten, Michael$$b9$$eLast author$$udkfz
000128879 773__ $$0PERI:(DE-600)1500497-1$$a10.1016/j.jneuroim.2016.05.014$$gVol. 297, p. 117 - 126$$p117 - 126$$tJournal of neuroimmunology$$v297$$x0165-5728$$y2016
000128879 909CO $$ooai:inrepo02.dkfz.de:128879$$pVDB
000128879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)1f4e474ebc02bd0cf008f2b9098525d2$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000128879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)1f1efec9a95d1778031cb6f0b19ba58b$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000128879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)22a10e47ef85d2b98a12b21a7f332e56$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000128879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)19ad2213f94e3900fa9a1b02f36b965a$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000128879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)e681100c540b628a2bdbd48772b4fb50$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000128879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000128879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)5ef8651b0f857b9c640aa5b1498c43b5$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000128879 9131_ $$0G:(DE-HGF)POF3-317$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vTranslational cancer research$$x0
000128879 9141_ $$y2016
000128879 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000128879 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ NEUROIMMUNOL : 2015
000128879 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000128879 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000128879 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000128879 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000128879 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000128879 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000128879 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000128879 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000128879 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000128879 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000128879 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000128879 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000128879 9201_ $$0I:(DE-He78)G808-20160331$$kG808$$lIMT IM Platform$$x0
000128879 9201_ $$0I:(DE-He78)B062-20160331$$kB062$$lPädiatrische Neuroonkologie$$x1
000128879 9201_ $$0I:(DE-He78)G370-20160331$$kG370$$lKKE Neuroonkologie$$x2
000128879 9201_ $$0I:(DE-He78)G160-20160331$$kG160$$lNeuroimmunologie und Hirntumorimmunologie$$x3
000128879 9201_ $$0I:(DE-He78)L101-20160331$$kL101$$lDKTK Heidelberg$$x4
000128879 980__ $$ajournal
000128879 980__ $$aVDB
000128879 980__ $$aI:(DE-He78)G808-20160331
000128879 980__ $$aI:(DE-He78)B062-20160331
000128879 980__ $$aI:(DE-He78)G370-20160331
000128879 980__ $$aI:(DE-He78)G160-20160331
000128879 980__ $$aI:(DE-He78)L101-20160331
000128879 980__ $$aUNRESTRICTED