TY  - JOUR
AU  - Kickingereder, Philipp
AU  - Götz, Michael
AU  - Muschelli, John
AU  - Wick, Antje
AU  - Neuberger, Ulf
AU  - Shinohara, Russell T
AU  - Sill, Martin
AU  - Nowosielski, Martha
AU  - Schlemmer, Heinz-Peter
AU  - Radbruch, Alexander
AU  - Wick, Wolfgang
AU  - Bendszus, Martin
AU  - Maier-Hein, Klaus
AU  - Bonekamp, David
TI  - Large-scale Radiomic Profiling of Recurrent Glioblastoma Identifies an Imaging Predictor for Stratifying Anti-Angiogenic Treatment Response.
JO  - Clinical cancer research
VL  - 22
IS  - 23
SN  - 1557-3265
CY  - Philadelphia, Pa. [u.a.]
PB  - AACR
M1  - DKFZ-2017-04907
SP  - 5765 - 5771
PY  - 2016
AB  - Antiangiogenic treatment with bevacizumab, a mAb to the VEGF, is the single most widely used therapeutic agent for patients with recurrent glioblastoma. A major challenge is that there are currently no validated biomarkers that can predict treatment outcome. Here we analyze the potential of radiomics, an emerging field of research that aims to utilize the full potential of medical imaging.A total of 4,842 quantitative MRI features were automatically extracted and analyzed from the multiparametric tumor of 172 patients (allocated to a discovery and validation set with a 2:1 ratio) with recurrent glioblastoma prior to bevacizumab treatment. Leveraging a high-throughput approach, radiomic features of patients in the discovery set were subjected to a supervised principal component (superpc) analysis to generate a prediction model for stratifying treatment outcome to antiangiogenic therapy by means of both progression-free and overall survival (PFS and OS).The superpc predictor stratified patients in the discovery set into a low or high risk group for PFS (HR = 1.60; P = 0.017) and OS (HR = 2.14; P < 0.001) and was successfully validated for patients in the validation set (HR = 1.85, P = 0.030 for PFS; HR = 2.60, P = 0.001 for OS).Our radiomic-based superpc signature emerges as a putative imaging biomarker for the identification of patients who may derive the most benefit from antiangiogenic therapy, advances the knowledge in the noninvasive characterization of brain tumors, and stresses the role of radiomics as a novel tool for improving decision support in cancer treatment at low cost. Clin Cancer Res; 22(23); 5765-71. ©2016 AACR.
LB  - PUB:(DE-HGF)16
C6  - pmid:27803067
C2  - pmc:PMC5503450
DO  - DOI:10.1158/1078-0432.CCR-16-0702
UR  - https://inrepo02.dkfz.de/record/128894
ER  -