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@ARTICLE{Klimpki:128910,
      author       = {G. Klimpki$^*$ and H. Mescher$^*$ and M. S. Akselrod and O.
                      Jäkel$^*$ and S. Greilich$^*$},
      title        = {{F}luence-based dosimetry of proton and heavier ion beams
                      using single track detectors.},
      journal      = {Physics in medicine and biology},
      volume       = {61},
      number       = {3},
      issn         = {1361-6560},
      address      = {Bristol},
      publisher    = {IOP Publ.},
      reportid     = {DKFZ-2017-04923},
      pages        = {1021 - 1040},
      year         = {2016},
      abstract     = {Due to their superior spatial resolution, small and
                      biocompatible fluorescent nuclear track detectors (FNTDs)
                      open up the possibility of characterizing swift heavy
                      charged particle fields on a single track level. Permanently
                      stored spectroscopic information such as energy deposition
                      and particle field composition is of particular importance
                      in heavy ion radiotherapy, since radiation quality is one of
                      the decisive predictors for clinical outcome. Findings
                      presented within this paper aim towards single track
                      reconstruction and fluence-based dosimetry of proton and
                      heavier ion fields. Three-dimensional information on
                      individual ion trajectories through the detector volume is
                      obtained using fully automated image processing software.
                      Angular distributions of multidirectional fields can be
                      measured accurately within  ±2° uncertainty. This
                      translates into less than $5\%$ overall fluence deviation
                      from the chosen irradiation reference. The combination of
                      single ion tracking with an improved energy loss calibration
                      curve based on 90 FNTD irradiations with protons as well as
                      helium, carbon and oxygen ions enables spectroscopic
                      analysis of a detector irradiated in Bragg peak proximity of
                      a 270 MeV u(-1) carbon ion field. Fluence-based dosimetry
                      results agree with treatment planning software reference.},
      keywords     = {Protons (NLM Chemicals)},
      cin          = {E040},
      ddc          = {570},
      cid          = {I:(DE-He78)E040-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26757791},
      doi          = {10.1088/0031-9155/61/3/1021},
      url          = {https://inrepo02.dkfz.de/record/128910},
}