%0 Journal Article
%A Korshunov, Andrey
%A Capper, David
%A Reuss, David
%A Schrimpf, Daniel
%A Ryzhova, Marina
%A Hovestadt, Volker
%A Sturm, Dominik
%A Meyer, Jochen
%A Jones, Chris
%A Zheludkova, Olga
%A Kumirova, Ella
%A Golanov, Andrey
%A Kool, Marcel
%A Schüller, Ulrich
%A Mittelbronn, Michel
%A Hasselblatt, Martin
%A Schittenhelm, Jens
%A Reifenberger, Guido
%A Herold-Mende, Christel
%A Lichter, Peter
%A von Deimling, Andreas
%A Pfister, Stefan
%A Jones, David
%T Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity.
%J Acta neuropathologica
%V 131
%N 1
%@ 1432-0533
%C Berlin
%I Springer
%M DKFZ-2017-04958
%P 137 - 146
%D 2016
%X In contrast to the relative morphological uniformity of histone H3 K27-mutant high-grade gliomas, H3 G34-mutant tumors present as a histopathologically heterogeneous group of neoplasms, with microscopic characteristics typical of either glioblastoma (GBM) or central nervous system primitive neuroectodermal tumors (CNS-PNET). In the current study, we performed an integrative clinical, histopathological and molecular analysis of 81 G34-mutant CNS tumors. Routinely prepared tumor tissues were investigated for genomic and epigenomic alterations. Despite their divergent histopathological appearance, CNS tumors with H3.3 G34 mutations displayed uniform epigenetic signatures, suggesting a single biological origin. Comparative cytogenetic analysis with other GBM subtypes disclosed a high frequency and high specificity of 3q and 4q loss across G34-mutant tumors. PDGFRA amplification was more common in cases with GBM than with PNET morphology (36 vs. 5 
%K Histones (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:26482474
%R 10.1007/s00401-015-1493-1
%U https://inrepo02.dkfz.de/record/128946