TY  - JOUR
AU  - Korshunov, Andrey
AU  - Capper, David
AU  - Reuss, David
AU  - Schrimpf, Daniel
AU  - Ryzhova, Marina
AU  - Hovestadt, Volker
AU  - Sturm, Dominik
AU  - Meyer, Jochen
AU  - Jones, Chris
AU  - Zheludkova, Olga
AU  - Kumirova, Ella
AU  - Golanov, Andrey
AU  - Kool, Marcel
AU  - Schüller, Ulrich
AU  - Mittelbronn, Michel
AU  - Hasselblatt, Martin
AU  - Schittenhelm, Jens
AU  - Reifenberger, Guido
AU  - Herold-Mende, Christel
AU  - Lichter, Peter
AU  - von Deimling, Andreas
AU  - Pfister, Stefan
AU  - Jones, David
TI  - Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity.
JO  - Acta neuropathologica
VL  - 131
IS  - 1
SN  - 1432-0533
CY  - Berlin
PB  - Springer
M1  - DKFZ-2017-04958
SP  - 137 - 146
PY  - 2016
AB  - In contrast to the relative morphological uniformity of histone H3 K27-mutant high-grade gliomas, H3 G34-mutant tumors present as a histopathologically heterogeneous group of neoplasms, with microscopic characteristics typical of either glioblastoma (GBM) or central nervous system primitive neuroectodermal tumors (CNS-PNET). In the current study, we performed an integrative clinical, histopathological and molecular analysis of 81 G34-mutant CNS tumors. Routinely prepared tumor tissues were investigated for genomic and epigenomic alterations. Despite their divergent histopathological appearance, CNS tumors with H3.3 G34 mutations displayed uniform epigenetic signatures, suggesting a single biological origin. Comparative cytogenetic analysis with other GBM subtypes disclosed a high frequency and high specificity of 3q and 4q loss across G34-mutant tumors. PDGFRA amplification was more common in cases with GBM than with PNET morphology (36 vs. 5 
KW  - Histones (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26482474
DO  - DOI:10.1007/s00401-015-1493-1
UR  - https://inrepo02.dkfz.de/record/128946
ER  -