TY - JOUR
AU - Korshunov, Andrey
AU - Capper, David
AU - Reuss, David
AU - Schrimpf, Daniel
AU - Ryzhova, Marina
AU - Hovestadt, Volker
AU - Sturm, Dominik
AU - Meyer, Jochen
AU - Jones, Chris
AU - Zheludkova, Olga
AU - Kumirova, Ella
AU - Golanov, Andrey
AU - Kool, Marcel
AU - Schüller, Ulrich
AU - Mittelbronn, Michel
AU - Hasselblatt, Martin
AU - Schittenhelm, Jens
AU - Reifenberger, Guido
AU - Herold-Mende, Christel
AU - Lichter, Peter
AU - von Deimling, Andreas
AU - Pfister, Stefan
AU - Jones, David
TI - Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity.
JO - Acta neuropathologica
VL - 131
IS - 1
SN - 1432-0533
CY - Berlin
PB - Springer
M1 - DKFZ-2017-04958
SP - 137 - 146
PY - 2016
AB - In contrast to the relative morphological uniformity of histone H3 K27-mutant high-grade gliomas, H3 G34-mutant tumors present as a histopathologically heterogeneous group of neoplasms, with microscopic characteristics typical of either glioblastoma (GBM) or central nervous system primitive neuroectodermal tumors (CNS-PNET). In the current study, we performed an integrative clinical, histopathological and molecular analysis of 81 G34-mutant CNS tumors. Routinely prepared tumor tissues were investigated for genomic and epigenomic alterations. Despite their divergent histopathological appearance, CNS tumors with H3.3 G34 mutations displayed uniform epigenetic signatures, suggesting a single biological origin. Comparative cytogenetic analysis with other GBM subtypes disclosed a high frequency and high specificity of 3q and 4q loss across G34-mutant tumors. PDGFRA amplification was more common in cases with GBM than with PNET morphology (36 vs. 5
KW - Histones (NLM Chemicals)
LB - PUB:(DE-HGF)16
C6 - pmid:26482474
DO - DOI:10.1007/s00401-015-1493-1
UR - https://inrepo02.dkfz.de/record/128946
ER -