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@ARTICLE{Kuehl:128973,
      author       = {R. Kuehl$^*$ and M. Schmidt$^*$ and P. Dreger and K.
                      Steindorf$^*$ and M. Bohus and J. Wiskemann$^*$},
      title        = {{D}eterminants of exercise adherence and contamination in a
                      randomized controlled trial in cancer patients during and
                      after allogeneic {HCT}.},
      journal      = {Supportive care in cancer},
      volume       = {24},
      number       = {10},
      issn         = {1433-7339},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DKFZ-2017-04985},
      pages        = {4327 - 4337},
      year         = {2016},
      abstract     = {Evidence from randomized controlled trials is growing that
                      exercise interventions are beneficial in cancer patients
                      receiving allogeneic stem cell transplantation (allo-HCT).
                      However, information about adherence to exercise
                      interventions and exercise contamination in control groups
                      is lacking. This information is crucial for the
                      interpretation of study results. We therefore examined the
                      determinants of exercise adherence and contamination in
                      different treatment periods during (inpatient) and after
                      (outpatient) allo-HCT.One hundred fifty-three patients
                      scheduled for allo-HCT were randomized to a 1-year partly
                      supervised exercise intervention (endurance and resistance
                      exercise) or to a control group. Adherence was assessed via
                      exercise logs and contamination via questionnaires.Adherence
                      varied between $66 \%$ (inpatient) and $78 \%$
                      (outpatient) in different treatment periods. During
                      (inpatient) transplantation period, higher adherence was
                      significantly associated with lower fatigue (P = 0.004)
                      and with having children at home (P = 0.049). Adherence
                      after discharge was positively associated with endurance
                      performance (P = 0.003); higher adherence after day 100
                      was associated with exercise activity prior allo-HCT
                      (P = 0.010) and higher adherence after discharge
                      (P = 0.001). Contamination among controls was high with
                      $54 \%$ and significantly associated with muscle strength
                      (P = 0.025) and fatigue (P = 0.050).Exercise
                      adherence in different treatment periods was determined by
                      different variables, and contamination among controls was
                      evident. These findings may have important implications for
                      correct interpretation of randomized exercise intervention
                      trials.},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27189616},
      doi          = {10.1007/s00520-016-3271-6},
      url          = {https://inrepo02.dkfz.de/record/128973},
}