TY  - JOUR
AU  - Lim, Hyun-ju
AU  - Weinheimer, Oliver
AU  - Wielpütz, Mark O
AU  - Dinkel, Julien
AU  - Hielscher, Thomas
AU  - Gompelmann, Daniela
AU  - Kauczor, Hans-Ulrich
AU  - Heussel, Claus Peter
TI  - Fully Automated Pulmonary Lobar Segmentation: Influence of Different Prototype Software Programs onto Quantitative Evaluation of Chronic Obstructive Lung Disease.
JO  - PLoS one
VL  - 11
IS  - 3
SN  - 1932-6203
CY  - Lawrence, Kan.
PB  - PLoS
M1  - DKFZ-2017-05060
SP  - e0151498 -
PY  - 2016
AB  - Surgical or bronchoscopic lung volume reduction (BLVR) techniques can be beneficial for heterogeneous emphysema. Post-processing software tools for lobar emphysema quantification are useful for patient and target lobe selection, treatment planning and post-interventional follow-up. We aimed to evaluate the inter-software variability of emphysema quantification using fully automated lobar segmentation prototypes.66 patients with moderate to severe COPD who underwent CT for planning of BLVR were included. Emphysema quantification was performed using 2 modified versions of in-house software (without and with prototype advanced lung vessel segmentation; programs 1 [YACTA v.2.3.0.2] and 2 [YACTA v.2.4.3.1]), as well as 1 commercial program 3 [Pulmo3D VA30A_HF2] and 1 pre-commercial prototype 4 [CT COPD ISP ver7.0]). The following parameters were computed for each segmented anatomical lung lobe and the whole lung: lobar volume (LV), mean lobar density (MLD), 15th percentile of lobar density (15th), emphysema volume (EV) and emphysema index (EI). Bland-Altman analysis (limits of agreement, LoA) and linear random effects models were used for comparison between the software.Segmentation using programs 1, 3 and 4 was unsuccessful in 1 (1
LB  - PUB:(DE-HGF)16
C6  - pmid:27029047
C2  - pmc:PMC4814108
DO  - DOI:10.1371/journal.pone.0151498
UR  - https://inrepo02.dkfz.de/record/129055
ER  -