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@ARTICLE{Mai:129106,
      author       = {E. K. Mai and T. Hielscher$^*$ and J. K. Kloth and M.
                      Merz$^*$ and S. Shah and M. Hillengass and B. Wagner and D.
                      Hose and M. S. Raab$^*$ and A. Jauch and S. Delorme$^*$ and
                      H. Goldschmidt and M.-A. Weber$^*$ and J. Hillengass$^*$},
      title        = {{A}ssociation between magnetic resonance imaging patterns
                      and baseline disease features in multiple myeloma: analyzing
                      surrogates of tumour mass and biology.},
      journal      = {European radiology},
      volume       = {26},
      number       = {11},
      issn         = {1432-1084},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DKFZ-2017-05111},
      pages        = {3939 - 3948},
      year         = {2016},
      abstract     = {To assess associations between bone marrow infiltration
                      patterns and localization in magnetic resonance imaging
                      (MRI) and baseline clinical/prognostic parameters in
                      multiple myeloma (MM).We compared baseline MM parameters,
                      MRI patterns and localization of focal lesions to the
                      mineralized bone in 206 newly diagnosed MM patients.A high
                      tumour mass (represented by International Staging System
                      stage III) was significantly associated with severe diffuse
                      infiltration (p = 0.015) and a higher number of focal
                      lesions (p = 0.006). Elevated creatinine
                      (p = 0.003), anaemia (p < 0.001) and high LDH
                      (p = 0.001) correlated with severe diffuse infiltration.
                      A salt and pepper diffuse pattern had a favourable
                      prognosis. A higher degree of destruction of mineralized
                      bone (assessed by X-ray or computed tomography) was
                      associated with an increasing number of focal lesions on MRI
                      (p < 0.001). Adverse cytogenetics
                      (del17p/gain1q21/t(4;14)) were associated with diffuse
                      infiltration (p = 0.008). The presence of intraosseous
                      focal lesions exceeding the mineralized bone had a
                      borderline significant impact on prognosis.Diffuse bone
                      marrow infiltration on MRI correlates with adverse
                      cytogenetics, lowered haemoglobin values and high tumour
                      burden in newly diagnosed MM whereas an increasing number of
                      focal lesions correlates with a higher degree of bone
                      destruction. Focal lesions exceeding the cortical bone did
                      not adversely affect the prognosis.• Diffuse MRI
                      correlates with adverse cytogenetics, lowered haemoglobin
                      and high tumour burden. • Higher numbers of MRI focal
                      lesions correlate with increasing degree of bone
                      destruction. • Focal lesions exceeding the cortical bone
                      borderline significantly influence survival. •
                      Moderate/severe diffuse infiltration and more than 23 focal
                      lesions adversely affect survival.},
      cin          = {C060 / E010 / G330},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331 / I:(DE-He78)E010-20160331 /
                      I:(DE-He78)G330-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26767378},
      doi          = {10.1007/s00330-015-4195-0},
      url          = {https://inrepo02.dkfz.de/record/129106},
}