TY  - JOUR
AU  - Mairani, A.
AU  - Magro, G.
AU  - Dokic, I.
AU  - Valle, S. M.
AU  - Tessonnier, T.
AU  - Galm, R.
AU  - Ciocca, M.
AU  - Parodi, K.
AU  - Ferrari, A.
AU  - Jäkel, O.
AU  - Haberer, T.
AU  - Pedroni, P.
AU  - Böhlen, T. T.
TI  - Data-driven RBE parameterization for helium ion beams.
JO  - Physics in medicine and biology
VL  - 61
IS  - 2
SN  - 1361-6560
CY  - Bristol
PB  - IOP Publ.
M1  - DKFZ-2017-05115
SP  - 888 - 905
PY  - 2016
AB  - Helium ion beams are expected to be available again in the near future for clinical use. A suitable formalism to obtain relative biological effectiveness (RBE) values for treatment planning (TP) studies is needed. In this work we developed a data-driven RBE parameterization based on published in vitro experimental values. The RBE parameterization has been developed within the framework of the linear-quadratic (LQ) model as a function of the helium linear energy transfer (LET), dose and the tissue specific parameter (α/β)ph of the LQ model for the reference radiation. Analytic expressions are provided, derived from the collected database, describing the RBEα = αHe/αph and Rβ = βHe/βph ratios as a function of LET. Calculated RBE values at 2 Gy photon dose and at 10
KW  - Radioisotopes (NLM Chemicals)
KW  - Helium (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26740518
DO  - DOI:10.1088/0031-9155/61/2/888
UR  - https://inrepo02.dkfz.de/record/129110
ER  -