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@ARTICLE{Mairani:129110,
      author       = {A. Mairani and G. Magro and I. Dokic$^*$ and S. M. Valle
                      and T. Tessonnier and R. Galm$^*$ and M. Ciocca and K.
                      Parodi and A. Ferrari and O. Jäkel$^*$ and T. Haberer and
                      P. Pedroni and T. T. Böhlen},
      title        = {{D}ata-driven {RBE} parameterization for helium ion beams.},
      journal      = {Physics in medicine and biology},
      volume       = {61},
      number       = {2},
      issn         = {1361-6560},
      address      = {Bristol},
      publisher    = {IOP Publ.},
      reportid     = {DKFZ-2017-05115},
      pages        = {888 - 905},
      year         = {2016},
      abstract     = {Helium ion beams are expected to be available again in the
                      near future for clinical use. A suitable formalism to obtain
                      relative biological effectiveness (RBE) values for treatment
                      planning (TP) studies is needed. In this work we developed a
                      data-driven RBE parameterization based on published in vitro
                      experimental values. The RBE parameterization has been
                      developed within the framework of the linear-quadratic (LQ)
                      model as a function of the helium linear energy transfer
                      (LET), dose and the tissue specific parameter (α/β)ph of
                      the LQ model for the reference radiation. Analytic
                      expressions are provided, derived from the collected
                      database, describing the RBEα = αHe/αph and Rβ =
                      βHe/βph ratios as a function of LET. Calculated RBE values
                      at 2 Gy photon dose and at $10\%$ survival (RBE10) are
                      compared with the experimental ones. Pearson's correlation
                      coefficients were, respectively, 0.85 and 0.84 confirming
                      the soundness of the introduced approach. Moreover, due to
                      the lack of experimental data at low LET, clonogenic
                      experiments have been performed irradiating A549 cell line
                      with (α/β)ph = 5.4 Gy at the entrance of a 56.4 MeV
                      u(-1)He beam at the Heidelberg Ion Beam Therapy Center. The
                      proposed parameterization reproduces the measured cell
                      survival within the experimental uncertainties. A RBE
                      formula, which depends only on dose, LET and (α/β)ph as
                      input parameters is proposed, allowing a straightforward
                      implementation in a TP system.},
      keywords     = {Radioisotopes (NLM Chemicals) / Helium (NLM Chemicals)},
      cin          = {E040 / E210 / L101},
      ddc          = {570},
      cid          = {I:(DE-He78)E040-20160331 / I:(DE-He78)E210-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26740518},
      doi          = {10.1088/0031-9155/61/2/888},
      url          = {https://inrepo02.dkfz.de/record/129110},
}