TY  - JOUR
AU  - Mascelli, Samantha
AU  - Nozza, Paolo
AU  - Jones, David
AU  - Colin, Carole
AU  - Pistorio, Angela
AU  - Milanaccio, Claudia
AU  - Ravegnani, Marcello
AU  - Consales, Alessandro
AU  - Witt, Olaf
AU  - Morana, Giovanni
AU  - Cama, Armando
AU  - Capra, Valeria
AU  - Biassoni, Roberto
AU  - Pfister, Stefan
AU  - Figarella-Branger, Dominique
AU  - Garrè, Maria Luisa
AU  - Raso, Alessandro
TI  - TP53 codon 72 polymorphism may predict early tumour progression in paediatric pilocytic astrocytoma.
JO  - OncoTarget
VL  - 7
IS  - 30
SN  - 1949-2553
CY  - [S.l.]
PB  - Impact Journals LLC
M1  - DKFZ-2017-05146
SP  - 47918 - 47926
PY  - 2016
AB  - Pilocytic astrocytoma and ganglioglioma may occur in inaccessible or surgically difficult areas. In case of incomplete resection, the availability of biological predictors of tumour progression could be particularly important. To this end, an analysis of p53 codon 72 polymorphism and assessment of its role as prognostic marker were performed.The status of the p53 Arg72Pro polymorphism was evaluated by pyrosequencing method in a multicenter cohort of 170 paediatric patients. Genotype/phenotype associations were investigated either by means of bivariate or multivariate analyses.In the partially resected pilocytic astrocytomas, the Arg/Arg variant predicts early tumour progression (median survival time: 23.1 months) and is associated with poor event-free survival (p value = 0.0009). This finding remains true also in case of adjuvant therapies, with a 5-year event-free survival of 30.6
LB  - PUB:(DE-HGF)16
C6  - pmid:27374106
C2  - pmc:PMC5216988
DO  - DOI:10.18632/oncotarget.10295
UR  - https://inrepo02.dkfz.de/record/129141
ER  -