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@ARTICLE{Mascelli:129141,
      author       = {S. Mascelli and P. Nozza and D. Jones$^*$ and C. Colin and
                      A. Pistorio and C. Milanaccio and M. Ravegnani and A.
                      Consales and O. Witt$^*$ and G. Morana and A. Cama and V.
                      Capra and R. Biassoni and S. Pfister$^*$ and D.
                      Figarella-Branger and M. L. Garrè and A. Raso},
      title        = {{TP}53 codon 72 polymorphism may predict early tumour
                      progression in paediatric pilocytic astrocytoma.},
      journal      = {OncoTarget},
      volume       = {7},
      number       = {30},
      issn         = {1949-2553},
      address      = {[S.l.]},
      publisher    = {Impact Journals LLC},
      reportid     = {DKFZ-2017-05146},
      pages        = {47918 - 47926},
      year         = {2016},
      abstract     = {Pilocytic astrocytoma and ganglioglioma may occur in
                      inaccessible or surgically difficult areas. In case of
                      incomplete resection, the availability of biological
                      predictors of tumour progression could be particularly
                      important. To this end, an analysis of p53 codon 72
                      polymorphism and assessment of its role as prognostic marker
                      were performed.The status of the p53 Arg72Pro polymorphism
                      was evaluated by pyrosequencing method in a multicenter
                      cohort of 170 paediatric patients. Genotype/phenotype
                      associations were investigated either by means of bivariate
                      or multivariate analyses.In the partially resected pilocytic
                      astrocytomas, the Arg/Arg variant predicts early tumour
                      progression (median survival time: 23.1 months) and is
                      associated with poor event-free survival (p value = 0.0009).
                      This finding remains true also in case of adjuvant
                      therapies, with a 5-year event-free survival of $30.6\%$ for
                      cases with Arg/Arg variant vs. $78.7\%$ for those with other
                      genotypes. There is no association between ganglioglioma and
                      the polymorphism.The assessment of Arg/Arg variant could
                      improve the management of pilocytic astrocytoma. TP53 codon
                      72 analysis could distinguish low-risk cases, in which
                      surgery could be conservative, from high-risk cases needing
                      an aggressive surgery plan.},
      cin          = {B062},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27374106},
      pmc          = {pmc:PMC5216988},
      doi          = {10.18632/oncotarget.10295},
      url          = {https://inrepo02.dkfz.de/record/129141},
}