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000129177 0247_ $$2doi$$a10.1016/j.devcel.2017.08.014
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000129177 037__ $$aDKFZ-2017-05182
000129177 041__ $$aeng
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000129177 1001_ $$aKempf, Anissa$$b0
000129177 245__ $$aControl of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction.
000129177 260__ $$aCambridge, Mass.$$bCell Press$$c2017
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000129177 520__ $$aHeparan sulfate proteoglycans (HSPGs) critically modulate adhesion-, growth-, and migration-related processes. Here, we show that the transmembrane protein, Nogo-A, inhibits neurite outgrowth and cell spreading in neurons and Nogo-A-responsive cell lines via HSPGs. The extracellular, active 180 amino acid Nogo-A region, named Nogo-A-Δ20, binds to heparin and brain-derived heparan sulfate glycosaminoglycans (GAGs) but not to the closely related chondroitin sulfate GAGs. HSPGs are required for Nogo-A-Δ20-induced inhibition of adhesion, cell spreading, and neurite outgrowth, as well as for RhoA activation. Surprisingly, we show that Nogo-A-Δ20 can act via HSPGs independently of its receptor, Sphingosine-1-Phosphate receptor 2 (S1PR2). We thereby identify the HSPG family members syndecan-3 and syndecan-4 as functional receptors for Nogo-A-Δ20. Finally, we show in explant cultures ex vivo that Nogo-A-Δ20 promotes the migration of neuroblasts via HSPGs but not S1PR2.
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000129177 650_7 $$2NLM Chemicals$$aCarrier Proteins
000129177 650_7 $$2NLM Chemicals$$aHeparan Sulfate Proteoglycans
000129177 650_7 $$2NLM Chemicals$$aNogo Proteins
000129177 650_7 $$2NLM Chemicals$$aProteoglycans
000129177 650_7 $$2NLM Chemicals$$aReceptors, Lysosphingolipid
000129177 650_7 $$09050-30-0$$2NLM Chemicals$$aHeparitin Sulfate
000129177 7001_ $$aBoda, Enrica$$b1
000129177 7001_ $$aKwok, Jessica C F$$b2
000129177 7001_ $$aFritz, Rafael$$b3
000129177 7001_ $$aGrande, Valentina$$b4
000129177 7001_ $$aKaelin, Andrea M$$b5
000129177 7001_ $$aRistic, Zorica$$b6
000129177 7001_ $$aSchmandke, Andre$$b7
000129177 7001_ $$aSchmandke, Antonio$$b8
000129177 7001_ $$0P:(DE-HGF)0$$aTews, Bjoern$$b9
000129177 7001_ $$aFawcett, James W$$b10
000129177 7001_ $$aPertz, Olivier$$b11
000129177 7001_ $$aBuffo, Annalisa$$b12
000129177 7001_ $$aSchwab, Martin E$$b13
000129177 773__ $$0PERI:(DE-600)2053870-4$$a10.1016/j.devcel.2017.08.014$$gVol. 43, no. 1, p. 24 - 34.e5$$n1$$p24 - 34.e5$$tDevelopmental cell$$v43$$x1534-5807$$y2017
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