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@ARTICLE{Kempf:129177,
      author       = {A. Kempf and E. Boda and J. C. F. Kwok and R. Fritz and V.
                      Grande and A. M. Kaelin and Z. Ristic and A. Schmandke and
                      A. Schmandke and B. Tews$^*$ and J. W. Fawcett and O. Pertz
                      and A. Buffo and M. E. Schwab},
      title        = {{C}ontrol of {C}ell {S}hape, {N}eurite {O}utgrowth, and
                      {M}igration by a {N}ogo-{A}/{HSPG} {I}nteraction.},
      journal      = {Developmental cell},
      volume       = {43},
      number       = {1},
      issn         = {1534-5807},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2017-05182},
      pages        = {24 - 34.e5},
      year         = {2017},
      abstract     = {Heparan sulfate proteoglycans (HSPGs) critically modulate
                      adhesion-, growth-, and migration-related processes. Here,
                      we show that the transmembrane protein, Nogo-A, inhibits
                      neurite outgrowth and cell spreading in neurons and
                      Nogo-A-responsive cell lines via HSPGs. The extracellular,
                      active 180 amino acid Nogo-A region, named Nogo-A-Δ20,
                      binds to heparin and brain-derived heparan sulfate
                      glycosaminoglycans (GAGs) but not to the closely related
                      chondroitin sulfate GAGs. HSPGs are required for
                      Nogo-A-Δ20-induced inhibition of adhesion, cell spreading,
                      and neurite outgrowth, as well as for RhoA activation.
                      Surprisingly, we show that Nogo-A-Δ20 can act via HSPGs
                      independently of its receptor, Sphingosine-1-Phosphate
                      receptor 2 (S1PR2). We thereby identify the HSPG family
                      members syndecan-3 and syndecan-4 as functional receptors
                      for Nogo-A-Δ20. Finally, we show in explant cultures
                      ex vivo that Nogo-A-Δ20 promotes the migration of
                      neuroblasts via HSPGs but not S1PR2.},
      keywords     = {Carrier Proteins (NLM Chemicals) / Heparan Sulfate
                      Proteoglycans (NLM Chemicals) / Nogo Proteins (NLM
                      Chemicals) / Proteoglycans (NLM Chemicals) / Receptors,
                      Lysosphingolipid (NLM Chemicals) / Heparitin Sulfate (NLM
                      Chemicals)},
      cin          = {V077},
      ddc          = {570},
      cid          = {I:(DE-He78)V077-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28943240},
      doi          = {10.1016/j.devcel.2017.08.014},
      url          = {https://inrepo02.dkfz.de/record/129177},
}