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| 001 | 129177 | ||
| 005 | 20240228145548.0 | ||
| 024 | 7 | _ | |a 10.1016/j.devcel.2017.08.014 |2 doi |
| 024 | 7 | _ | |a pmid:28943240 |2 pmid |
| 024 | 7 | _ | |a 1534-5807 |2 ISSN |
| 024 | 7 | _ | |a 1878-1551 |2 ISSN |
| 024 | 7 | _ | |a altmetric:28334883 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-05182 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Kempf, Anissa |b 0 |
| 245 | _ | _ | |a Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction. |
| 260 | _ | _ | |a Cambridge, Mass. |c 2017 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1511353239_28996 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Heparan sulfate proteoglycans (HSPGs) critically modulate adhesion-, growth-, and migration-related processes. Here, we show that the transmembrane protein, Nogo-A, inhibits neurite outgrowth and cell spreading in neurons and Nogo-A-responsive cell lines via HSPGs. The extracellular, active 180 amino acid Nogo-A region, named Nogo-A-Δ20, binds to heparin and brain-derived heparan sulfate glycosaminoglycans (GAGs) but not to the closely related chondroitin sulfate GAGs. HSPGs are required for Nogo-A-Δ20-induced inhibition of adhesion, cell spreading, and neurite outgrowth, as well as for RhoA activation. Surprisingly, we show that Nogo-A-Δ20 can act via HSPGs independently of its receptor, Sphingosine-1-Phosphate receptor 2 (S1PR2). We thereby identify the HSPG family members syndecan-3 and syndecan-4 as functional receptors for Nogo-A-Δ20. Finally, we show in explant cultures ex vivo that Nogo-A-Δ20 promotes the migration of neuroblasts via HSPGs but not S1PR2. |
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| 650 | _ | 7 | |a Carrier Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Heparan Sulfate Proteoglycans |2 NLM Chemicals |
| 650 | _ | 7 | |a Nogo Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Proteoglycans |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, Lysosphingolipid |2 NLM Chemicals |
| 650 | _ | 7 | |a Heparitin Sulfate |0 9050-30-0 |2 NLM Chemicals |
| 700 | 1 | _ | |a Boda, Enrica |b 1 |
| 700 | 1 | _ | |a Kwok, Jessica C F |b 2 |
| 700 | 1 | _ | |a Fritz, Rafael |b 3 |
| 700 | 1 | _ | |a Grande, Valentina |b 4 |
| 700 | 1 | _ | |a Kaelin, Andrea M |b 5 |
| 700 | 1 | _ | |a Ristic, Zorica |b 6 |
| 700 | 1 | _ | |a Schmandke, Andre |b 7 |
| 700 | 1 | _ | |a Schmandke, Antonio |b 8 |
| 700 | 1 | _ | |a Tews, Bjoern |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Fawcett, James W |b 10 |
| 700 | 1 | _ | |a Pertz, Olivier |b 11 |
| 700 | 1 | _ | |a Buffo, Annalisa |b 12 |
| 700 | 1 | _ | |a Schwab, Martin E |b 13 |
| 773 | _ | _ | |a 10.1016/j.devcel.2017.08.014 |g Vol. 43, no. 1, p. 24 - 34.e5 |0 PERI:(DE-600)2053870-4 |n 1 |p 24 - 34.e5 |t Developmental cell |v 43 |y 2017 |x 1534-5807 |
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