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@ARTICLE{Larribre:129179,
      author       = {L. Larribère$^*$ and M. Galach$^*$ and D. Novak$^*$ and K.
                      Arévalo$^*$ and H. C. Volz$^*$ and H.-J. Stark$^*$ and P.
                      Boukamp$^*$ and M. Boutros$^*$ and J. Utikal$^*$},
      title        = {{A}n {RNA}i {S}creen {R}eveals an {E}ssential {R}ole for
                      {HIPK}4 in {H}uman {S}kin {E}pithelial {D}ifferentiation
                      from i{PSC}s.},
      journal      = {Stem cell reports},
      volume       = {9},
      number       = {4},
      issn         = {2213-6711},
      address      = {Maryland Heights, MO},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2017-05184},
      pages        = {1234 - 1245},
      year         = {2017},
      abstract     = {Molecular mechanisms responsible for the development of
                      human skin epithelial cells are incompletely understood. As
                      a consequence, the efficiency to establish a pure skin
                      epithelial cell population from human induced pluripotent
                      stem cells (hiPSCs) remains poor. Using an approach
                      including RNAi and high-throughput imaging of early
                      epithelial cells, we identified candidate kinases involved
                      in their differentiation from hiPSCs. Among these, we found
                      HIPK4 to be an important inhibitor of this process. Indeed,
                      its silencing increased the amount of generated skin
                      epithelial precursors at an early time point, increased the
                      amount of generated keratinocytes at a later time point, and
                      improved growth and differentiation of organotypic cultures,
                      allowing for the formation of a denser basal layer and
                      stratification with the expression of several keratins. Our
                      data bring substantial input regarding regulation of human
                      skin epithelial differentiation and for improving
                      differentiation protocols from pluripotent stem cells.},
      cin          = {G300 / B110 / A110},
      ddc          = {610},
      cid          = {I:(DE-He78)G300-20160331 / I:(DE-He78)B110-20160331 /
                      I:(DE-He78)A110-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28966120},
      pmc          = {pmc:PMC5639458},
      doi          = {10.1016/j.stemcr.2017.08.023},
      url          = {https://inrepo02.dkfz.de/record/129179},
}