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000129181 0247_ $$2doi$$a10.1016/j.ccell.2017.08.017
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000129181 0247_ $$2pmc$$apmc:PMC5637314
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000129181 0247_ $$2ISSN$$a1878-3686
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000129181 037__ $$aDKFZ-2017-05186
000129181 041__ $$aeng
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000129181 1001_ $$aMackay, Alan$$b0
000129181 245__ $$aIntegrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.
000129181 260__ $$aCambridge, Mass.$$bCell Press$$c2017
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000129181 520__ $$aWe collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grade tumors. Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct. Uncommon pathway dysregulation is seen in small subsets of tumors, further defining the molecular diversity of the disease, opening up avenues for biological study and providing a basis for functionally defined future treatment stratification.
000129181 536__ $$0G:(DE-HGF)POF3-312$$a312 - Functional and structural genomics (POF3-312)$$cPOF3-312$$fPOF III$$x0
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000129181 650_7 $$2NLM Chemicals$$aBCOR protein, human
000129181 650_7 $$2NLM Chemicals$$aCell Cycle Proteins
000129181 650_7 $$2NLM Chemicals$$aF-Box Proteins
000129181 650_7 $$2NLM Chemicals$$aHistones
000129181 650_7 $$2NLM Chemicals$$aProto-Oncogene Proteins
000129181 650_7 $$2NLM Chemicals$$aRepressor Proteins
000129181 650_7 $$0EC 2.3.2.27$$2NLM Chemicals$$aUbiquitin-Protein Ligases
000129181 650_7 $$0EC 5.99.1.2$$2NLM Chemicals$$aDNA Topoisomerases, Type I
000129181 650_7 $$0EC 5.99.1.2$$2NLM Chemicals$$aDNA topoisomerase III
000129181 650_7 $$0EC 6.3.2.19$$2NLM Chemicals$$aFBXW7 protein, human
000129181 7001_ $$aBurford, Anna$$b1
000129181 7001_ $$aCarvalho, Diana$$b2
000129181 7001_ $$aIzquierdo, Elisa$$b3
000129181 7001_ $$aFazal-Salom, Janat$$b4
000129181 7001_ $$aTaylor, Kathryn R$$b5
000129181 7001_ $$aBjerke, Lynn$$b6
000129181 7001_ $$aClarke, Matthew$$b7
000129181 7001_ $$aVinci, Mara$$b8
000129181 7001_ $$aNandhabalan, Meera$$b9
000129181 7001_ $$aTemelso, Sara$$b10
000129181 7001_ $$aPopov, Sergey$$b11
000129181 7001_ $$aMolinari, Valeria$$b12
000129181 7001_ $$aRaman, Pichai$$b13
000129181 7001_ $$aWaanders, Angela J$$b14
000129181 7001_ $$aHan, Harry J$$b15
000129181 7001_ $$aGupta, Saumya$$b16
000129181 7001_ $$aMarshall, Lynley$$b17
000129181 7001_ $$aZacharoulis, Stergios$$b18
000129181 7001_ $$aVaidya, Sucheta$$b19
000129181 7001_ $$aMandeville, Henry C$$b20
000129181 7001_ $$aBridges, Leslie R$$b21
000129181 7001_ $$aMartin, Andrew J$$b22
000129181 7001_ $$aAl-Sarraj, Safa$$b23
000129181 7001_ $$aChandler, Christopher$$b24
000129181 7001_ $$aNg, Ho-Keung$$b25
000129181 7001_ $$aLi, Xingang$$b26
000129181 7001_ $$aMu, Kun$$b27
000129181 7001_ $$aTrabelsi, Saoussen$$b28
000129181 7001_ $$aBrahim, Dorra H'mida-Ben$$b29
000129181 7001_ $$aKisljakov, Alexei N$$b30
000129181 7001_ $$aKonovalov, Dmitry M$$b31
000129181 7001_ $$aMoore, Andrew S$$b32
000129181 7001_ $$aCarcaboso, Angel Montero$$b33
000129181 7001_ $$aSunol, Mariona$$b34
000129181 7001_ $$ade Torres, Carmen$$b35
000129181 7001_ $$aCruz, Ofelia$$b36
000129181 7001_ $$aMora, Jaume$$b37
000129181 7001_ $$aShats, Ludmila I$$b38
000129181 7001_ $$aStavale, João N$$b39
000129181 7001_ $$aBidinotto, Lucas T$$b40
000129181 7001_ $$aReis, Rui M$$b41
000129181 7001_ $$aEntz-Werle, Natacha$$b42
000129181 7001_ $$aFarrell, Michael$$b43
000129181 7001_ $$aCryan, Jane$$b44
000129181 7001_ $$aCrimmins, Darach$$b45
000129181 7001_ $$aCaird, John$$b46
000129181 7001_ $$aPears, Jane$$b47
000129181 7001_ $$aMonje, Michelle$$b48
000129181 7001_ $$aDebily, Marie-Anne$$b49
000129181 7001_ $$aCastel, David$$b50
000129181 7001_ $$aGrill, Jacques$$b51
000129181 7001_ $$aHawkins, Cynthia$$b52
000129181 7001_ $$aNikbakht, Hamid$$b53
000129181 7001_ $$aJabado, Nada$$b54
000129181 7001_ $$aBaker, Suzanne J$$b55
000129181 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b56$$udkfz
000129181 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b57$$udkfz
000129181 7001_ $$aFouladi, Maryam$$b58
000129181 7001_ $$avon Bueren, André O$$b59
000129181 7001_ $$aBaudis, Michael$$b60
000129181 7001_ $$aResnick, Adam$$b61
000129181 7001_ $$aJones, Chris$$b62
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