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| Home > Publications database > Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. > print |
| 001 | 129181 | ||
| 005 | 20240228145548.0 | ||
| 024 | 7 | _ | |a 10.1016/j.ccell.2017.08.017 |2 doi |
| 024 | 7 | _ | |a pmid:28966033 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC5637314 |2 pmc |
| 024 | 7 | _ | |a 1535-6108 |2 ISSN |
| 024 | 7 | _ | |a 1878-3686 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2017-05186 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Mackay, Alan |b 0 |
| 245 | _ | _ | |a Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. |
| 260 | _ | _ | |a Cambridge, Mass. |c 2017 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1510750894_10555 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grade tumors. Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct. Uncommon pathway dysregulation is seen in small subsets of tumors, further defining the molecular diversity of the disease, opening up avenues for biological study and providing a basis for functionally defined future treatment stratification. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a BCOR protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Cell Cycle Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a F-Box Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Histones |2 NLM Chemicals |
| 650 | _ | 7 | |a Proto-Oncogene Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Repressor Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Ubiquitin-Protein Ligases |0 EC 2.3.2.27 |2 NLM Chemicals |
| 650 | _ | 7 | |a DNA Topoisomerases, Type I |0 EC 5.99.1.2 |2 NLM Chemicals |
| 650 | _ | 7 | |a DNA topoisomerase III |0 EC 5.99.1.2 |2 NLM Chemicals |
| 650 | _ | 7 | |a FBXW7 protein, human |0 EC 6.3.2.19 |2 NLM Chemicals |
| 700 | 1 | _ | |a Burford, Anna |b 1 |
| 700 | 1 | _ | |a Carvalho, Diana |b 2 |
| 700 | 1 | _ | |a Izquierdo, Elisa |b 3 |
| 700 | 1 | _ | |a Fazal-Salom, Janat |b 4 |
| 700 | 1 | _ | |a Taylor, Kathryn R |b 5 |
| 700 | 1 | _ | |a Bjerke, Lynn |b 6 |
| 700 | 1 | _ | |a Clarke, Matthew |b 7 |
| 700 | 1 | _ | |a Vinci, Mara |b 8 |
| 700 | 1 | _ | |a Nandhabalan, Meera |b 9 |
| 700 | 1 | _ | |a Temelso, Sara |b 10 |
| 700 | 1 | _ | |a Popov, Sergey |b 11 |
| 700 | 1 | _ | |a Molinari, Valeria |b 12 |
| 700 | 1 | _ | |a Raman, Pichai |b 13 |
| 700 | 1 | _ | |a Waanders, Angela J |b 14 |
| 700 | 1 | _ | |a Han, Harry J |b 15 |
| 700 | 1 | _ | |a Gupta, Saumya |b 16 |
| 700 | 1 | _ | |a Marshall, Lynley |b 17 |
| 700 | 1 | _ | |a Zacharoulis, Stergios |b 18 |
| 700 | 1 | _ | |a Vaidya, Sucheta |b 19 |
| 700 | 1 | _ | |a Mandeville, Henry C |b 20 |
| 700 | 1 | _ | |a Bridges, Leslie R |b 21 |
| 700 | 1 | _ | |a Martin, Andrew J |b 22 |
| 700 | 1 | _ | |a Al-Sarraj, Safa |b 23 |
| 700 | 1 | _ | |a Chandler, Christopher |b 24 |
| 700 | 1 | _ | |a Ng, Ho-Keung |b 25 |
| 700 | 1 | _ | |a Li, Xingang |b 26 |
| 700 | 1 | _ | |a Mu, Kun |b 27 |
| 700 | 1 | _ | |a Trabelsi, Saoussen |b 28 |
| 700 | 1 | _ | |a Brahim, Dorra H'mida-Ben |b 29 |
| 700 | 1 | _ | |a Kisljakov, Alexei N |b 30 |
| 700 | 1 | _ | |a Konovalov, Dmitry M |b 31 |
| 700 | 1 | _ | |a Moore, Andrew S |b 32 |
| 700 | 1 | _ | |a Carcaboso, Angel Montero |b 33 |
| 700 | 1 | _ | |a Sunol, Mariona |b 34 |
| 700 | 1 | _ | |a de Torres, Carmen |b 35 |
| 700 | 1 | _ | |a Cruz, Ofelia |b 36 |
| 700 | 1 | _ | |a Mora, Jaume |b 37 |
| 700 | 1 | _ | |a Shats, Ludmila I |b 38 |
| 700 | 1 | _ | |a Stavale, João N |b 39 |
| 700 | 1 | _ | |a Bidinotto, Lucas T |b 40 |
| 700 | 1 | _ | |a Reis, Rui M |b 41 |
| 700 | 1 | _ | |a Entz-Werle, Natacha |b 42 |
| 700 | 1 | _ | |a Farrell, Michael |b 43 |
| 700 | 1 | _ | |a Cryan, Jane |b 44 |
| 700 | 1 | _ | |a Crimmins, Darach |b 45 |
| 700 | 1 | _ | |a Caird, John |b 46 |
| 700 | 1 | _ | |a Pears, Jane |b 47 |
| 700 | 1 | _ | |a Monje, Michelle |b 48 |
| 700 | 1 | _ | |a Debily, Marie-Anne |b 49 |
| 700 | 1 | _ | |a Castel, David |b 50 |
| 700 | 1 | _ | |a Grill, Jacques |b 51 |
| 700 | 1 | _ | |a Hawkins, Cynthia |b 52 |
| 700 | 1 | _ | |a Nikbakht, Hamid |b 53 |
| 700 | 1 | _ | |a Jabado, Nada |b 54 |
| 700 | 1 | _ | |a Baker, Suzanne J |b 55 |
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| 700 | 1 | _ | |a Fouladi, Maryam |b 58 |
| 700 | 1 | _ | |a von Bueren, André O |b 59 |
| 700 | 1 | _ | |a Baudis, Michael |b 60 |
| 700 | 1 | _ | |a Resnick, Adam |b 61 |
| 700 | 1 | _ | |a Jones, Chris |b 62 |
| 773 | _ | _ | |a 10.1016/j.ccell.2017.08.017 |g Vol. 32, no. 4, p. 520 - 537.e5 |0 PERI:(DE-600)2074034-7 |n 4 |p 520 - 537.e5 |t Cancer cell |v 32 |y 2017 |x 1535-6108 |
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