%0 Journal Article
%A Zeisbrich, M.
%A Becker, Natalia
%A Benner, A.
%A Radujkovic, A.
%A Schmitt, K.
%A Beimler, J.
%A Ho, A. D.
%A Zeier, M.
%A Dreger, P.
%A Luft, T.
%T Transplant-associated thrombotic microangiopathy is an endothelial complication associated with refractoriness of acute GvHD.
%J Bone marrow transplantation
%V 52
%N 10
%@ 0268-3369
%C London
%I Nature Publishing Group55086
%M DKFZ-2017-05199
%P 1399-1405
%D 2017
%X There is increasing evidence that endothelial dysfunction is involved in refractoriness of acute GvHD (aGvHD). Here we investigated the hypothesis that another endothelial complication, transplant-associated thrombotic microangiopathy (TMA), contributes to the pathogenesis of aGvHD refractoriness. TMA was retrospectively assessed in 771 patients after allogeneic stem cell transplantation (alloSCT). Incidences of TMA and refractory aGvHD were correlated with biomarkers of endothelial damage obtained before alloSCT for patients receiving or not receiving statin-based endothelial prophylaxis (SEP). Diagnostic criteria for TMA and refractory aGvHD were met by 41 (5.3
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28650448
%R 10.1038/bmt.2017.119
%U https://inrepo02.dkfz.de/record/129194