%0 Journal Article
%A Merz, Maximilian
%A Moehler, Thomas M
%A Ritsch, Judith
%A Bäuerle, Tobias
%A Zechmann, Christian M
%A Wagner, Barbara
%A Jauch, Anna
%A Hose, Dirk
%A Kunz, Christina
%A Hielscher, Thomas
%A Laue, Hendrik
%A Goldschmidt, Hartmut
%A Delorme, Stefan
%A Hillengass, Jens
%T Prognostic significance of increased bone marrow microcirculation in newly diagnosed multiple myeloma: results of a prospective DCE-MRI study.
%J European radiology
%V 26
%N 5
%@ 1432-1084
%C Berlin
%I Springer
%M DKFZ-2017-05242
%P 1404 - 1411
%D 2016
%X Aim of this prospective study was to investigate prognostic significance of increased bone marrow microcirculation as detected by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for survival and local complications in patients with multiple myeloma (MM).We performed DCE-MRI of the lumbar spine in 131 patients with newly diagnosed MM and analysed data according to the Brix model to acquire amplitude A and exchange rate constant kep. In 61 patients a second MRI performed after therapy was evaluated to assess changes in vertebral height and identify vertebral fractures.Correlation analysis revealed significant positive association between beta2-microglobulin as well as immunoparesis with DCE-MRI parameters A and kep. Additionally, A was negatively correlated with haemoglobin levels and kep was positively correlated with LDH levels. Higher baseline kep values were associated with decreased vertebral height in a second MRI (P = 0.007) and A values were associated with new vertebral fractures in the lower lumbar spine (P = 0.03 for L4). Pre-existing lytic bone lesions or remission after therapy had no impact on the occurrence of vertebral fractures. Multivariate analysis revealed that amplitude A is an independent adverse risk factor for overall survival.DCE-MRI is a non-invasive tool with significance for systemic prognosis and vertebral complications.• Qualitative parameters from DCE-MRI are correlated with established factors of disease activity • Increased marrow microcirculation might be a risk factor for loss of vertebral height and fractures • Amplitude A is an independent predictor for shortened overall survival.
%K Contrast Media (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:26215436
%R 10.1007/s00330-015-3928-4
%U https://inrepo02.dkfz.de/record/129237