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000129237 0247_ $$2ISSN$$a1432-1084
000129237 0247_ $$2ISSN$$a1613-3749
000129237 0247_ $$2ISSN$$a1613-3757
000129237 037__ $$aDKFZ-2017-05242
000129237 041__ $$aeng
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000129237 1001_ $$0P:(DE-HGF)0$$aMerz, Maximilian$$b0$$eFirst author
000129237 245__ $$aPrognostic significance of increased bone marrow microcirculation in newly diagnosed multiple myeloma: results of a prospective DCE-MRI study.
000129237 260__ $$aBerlin$$bSpringer$$c2016
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000129237 520__ $$aAim of this prospective study was to investigate prognostic significance of increased bone marrow microcirculation as detected by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for survival and local complications in patients with multiple myeloma (MM).We performed DCE-MRI of the lumbar spine in 131 patients with newly diagnosed MM and analysed data according to the Brix model to acquire amplitude A and exchange rate constant kep. In 61 patients a second MRI performed after therapy was evaluated to assess changes in vertebral height and identify vertebral fractures.Correlation analysis revealed significant positive association between beta2-microglobulin as well as immunoparesis with DCE-MRI parameters A and kep. Additionally, A was negatively correlated with haemoglobin levels and kep was positively correlated with LDH levels. Higher baseline kep values were associated with decreased vertebral height in a second MRI (P = 0.007) and A values were associated with new vertebral fractures in the lower lumbar spine (P = 0.03 for L4). Pre-existing lytic bone lesions or remission after therapy had no impact on the occurrence of vertebral fractures. Multivariate analysis revealed that amplitude A is an independent adverse risk factor for overall survival.DCE-MRI is a non-invasive tool with significance for systemic prognosis and vertebral complications.• Qualitative parameters from DCE-MRI are correlated with established factors of disease activity • Increased marrow microcirculation might be a risk factor for loss of vertebral height and fractures • Amplitude A is an independent predictor for shortened overall survival.
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000129237 7001_ $$aMoehler, Thomas M$$b1
000129237 7001_ $$aRitsch, Judith$$b2
000129237 7001_ $$aBäuerle, Tobias$$b3
000129237 7001_ $$aZechmann, Christian M$$b4
000129237 7001_ $$0P:(DE-HGF)0$$aWagner, Barbara$$b5
000129237 7001_ $$aJauch, Anna$$b6
000129237 7001_ $$aHose, Dirk$$b7
000129237 7001_ $$0P:(DE-He78)a9f6104e5c2c26345dcb242e6bdcb2b2$$aKunz, Christina$$b8$$udkfz
000129237 7001_ $$0P:(DE-He78)743a4a82daab55306a2c88b9f6bf8c2f$$aHielscher, Thomas$$b9$$udkfz
000129237 7001_ $$aLaue, Hendrik$$b10
000129237 7001_ $$0P:(DE-He78)a1aa959d47e3e026abe157a8adf24b96$$aGoldschmidt, Hartmut$$b11$$udkfz
000129237 7001_ $$0P:(DE-He78)3e76653311420a51a5faeb80363bd73e$$aDelorme, Stefan$$b12$$udkfz
000129237 7001_ $$0P:(DE-He78)7ccc574e713526d2a22d7acb9b2248c5$$aHillengass, Jens$$b13$$eLast author$$udkfz
000129237 773__ $$0PERI:(DE-600)1472718-3$$a10.1007/s00330-015-3928-4$$gVol. 26, no. 5, p. 1404 - 1411$$n5$$p1404 - 1411$$tEuropean radiology$$v26$$x1432-1084$$y2016
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